Expression of ECHDC1 in cancer - Summary - The Human Protein Atlas

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ECHDC1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ECHDC1
Gene description	Ethylmalonyl-CoA decarboxylase 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General, often granular, cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA035445
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035445

GENE INFORMATION
Gene name	ECHDC1 (HGNC Symbol)
Synonyms	dJ351K20.2
Description	Ethylmalonyl-CoA decarboxylase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	q22.33
Chromosome location (bp)	127288710 - 127343609
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000093144 (version 83.38)
Entrez gene	55862
UniProt	Q9NTX5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NTX5
Antibodypedia	ECHDC1 antibodies

PROTEIN BROWSER

ECHDC1-002	ECHDC1-004	ECHDC1-006	ECHDC1-007	ECHDC1-008	ECHDC1-009	ECHDC1-010	ECHDC1-012	ECHDC1-013	ECHDC1-016	ECHDC1-018	ECHDC1-020	ECHDC1-021	ECHDC1-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECHDC1-002 ENSP00000434908 ENST00000474289	Q9NTX5 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004492 [methylmalonyl-CoA decarboxylase activity] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0016831 [carboxy-lyase activity] GO:0070062 [extracellular exosome] Show all	301 aa 33 kDa	No	0
ECHDC1-004 ENSP00000357272 ENST00000368289	Q9NTX5 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004492 [methylmalonyl-CoA decarboxylase activity] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0016831 [carboxy-lyase activity] GO:0070062 [extracellular exosome] Show all	145 aa 15.9 kDa	No	0
ECHDC1-006 ENSP00000402492 ENST00000430841	Q9NTX5 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004492 [methylmalonyl-CoA decarboxylase activity] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0016831 [carboxy-lyase activity] GO:0070062 [extracellular exosome] Show all	301 aa 33 kDa	No	0
ECHDC1-007 ENSP00000404866 ENST00000454591	Q9NTX5 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004492 [methylmalonyl-CoA decarboxylase activity] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0016831 [carboxy-lyase activity] GO:0070062 [extracellular exosome] Show all	226 aa 24.9 kDa	No	0
ECHDC1-008 ENSP00000433015 ENST00000461239	H0YD54 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	34 aa 3.6 kDa	Yes	0
ECHDC1-009 ENSP00000357274 ENST00000368291	Q9NTX5 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004492 [methylmalonyl-CoA decarboxylase activity] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0016831 [carboxy-lyase activity] GO:0070062 [extracellular exosome] Show all	145 aa 15.9 kDa	No	0
ECHDC1-010 ENSP00000401751 ENST00000454859	Q9NTX5 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004492 [methylmalonyl-CoA decarboxylase activity] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0016831 [carboxy-lyase activity] GO:0070062 [extracellular exosome] Show all	301 aa 33 kDa	No	0
ECHDC1-012 ENSP00000432265 ENST00000460558	H0YCS9 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	100 aa 10.7 kDa	No	0
ECHDC1-013 ENSP00000436585 ENST00000531967	Q9NTX5 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004492 [methylmalonyl-CoA decarboxylase activity] GO:0005829 [cytosol] GO:0008152 [metabolic process] GO:0016831 [carboxy-lyase activity] GO:0070062 [extracellular exosome] Show all	307 aa 33.7 kDa	No	0
ECHDC1-016 ENSP00000399233 ENST00000436638	H0Y5L2 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	255 aa 28.2 kDa	No	0
ECHDC1-018 ENSP00000436109 ENST00000528402	Q9NTX5 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004492 [methylmalonyl-CoA decarboxylase activity] GO:0005829 [cytosol] GO:0016831 [carboxy-lyase activity] GO:0070062 [extracellular exosome] Show all	70 aa 7.7 kDa	No	0
ECHDC1-020 ENSP00000435068 ENST00000525745	E9PLY6 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	179 aa 19.9 kDa	No	0
ECHDC1-021 ENSP00000434143 ENST00000531582	E9PRU6 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	135 aa 14.7 kDa	No	0
ECHDC1-022 ENSP00000435502 ENST00000534442	E9PJS8 [Direct mapping] Ethylmalonyl-CoA decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	151 aa 16.6 kDa	No	0

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The Human Protein Atlas

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