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HDAC6

GENERAL INFORMATION

Gene name

 HDAC6

Gene description

 Histone deacetylase 6

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most cell types, most abundant in renal tubules and cells in seminiferus ducts.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA003714 , HPA026321 , CAB004236
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003714
HPA026321
CAB004236

GENE INFORMATION

Gene name

 HDAC6 (HGNC Symbol)

Synonyms

 FLJ16239, HD6, JM21, KIAA0901, PPP1R90

Description

 Histone deacetylase 6 (HGNC Symbol)

Entrez gene summary

 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48801377 - 48824982

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000094631 (version 83.38)

Entrez gene

 10013

UniProt

 Q9UBN7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBN7

Antibodypedia

 HDAC6 antibodies

PROTEIN BROWSER
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HDAC6-001
HDAC6-007
HDAC6-015
HDAC6-016
HDAC6-017
HDAC6-020
HDAC6-021
HDAC6-023
HDAC6-028
HDAC6-030
HDAC6-031
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HDAC6-001
ENSP00000334061
ENST00000334136
Q9UBN7 [Direct mapping]
Histone deacetylase 6
A0A024QZ26 [Target identity:100%; Query identity:100%]
Histone deacetylase 6, isoform CRA_c
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000209 [protein polyubiquitination]
GO:0001047 [core promoter binding]
GO:0003779 [actin binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005881 [cytoplasmic microtubule]
GO:0005901 [caveola]
GO:0006351 [transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006515 [misfolded or incompletely synthesized protein catabolic process]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0008013 [beta-catenin binding]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0009636 [response to toxic substance]
GO:0009967 [positive regulation of signal transduction]
GO:0010033 [response to organic substance]
GO:0010469 [regulation of receptor activity]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010727 [negative regulation of hydrogen peroxide metabolic process]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0016234 [inclusion body]
GO:0016235 [aggresome]
GO:0016236 [macroautophagy]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0030286 [dynein complex]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031252 [cell leading edge]
GO:0031593 [polyubiquitin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032418 [lysosome localization]
GO:0034605 [cellular response to heat]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035967 [cellular response to topologically incorrect protein]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042826 [histone deacetylase binding]
GO:0042903 [tubulin deacetylase activity]
GO:0043014 [alpha-tubulin binding]
GO:0043130 [ubiquitin binding]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0043204 [perikaryon]
GO:0043234 [protein complex]
GO:0043241 [protein complex disassembly]
GO:0043242 [negative regulation of protein complex disassembly]
GO:0045598 [regulation of fat cell differentiation]
GO:0045861 [negative regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048487 [beta-tubulin binding]
GO:0051354 [negative regulation of oxidoreductase activity]
GO:0051646 [mitochondrion localization]
GO:0051787 [misfolded protein binding]
GO:0051788 [response to misfolded protein]
GO:0051879 [Hsp90 protein binding]
GO:0060632 [regulation of microtubule-based movement]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0070201 [regulation of establishment of protein localization]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070840 [dynein complex binding]
GO:0070842 [aggresome assembly]
GO:0070845 [polyubiquitinated misfolded protein transport]
GO:0070846 [Hsp90 deacetylation]
GO:0070848 [response to growth factor]
GO:0070932 [histone H3 deacetylation]
GO:0071218 [cellular response to misfolded protein]
GO:0090035 [positive regulation of chaperone-mediated protein complex assembly]
GO:0090042 [tubulin deacetylation]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901300 [positive regulation of hydrogen peroxide-mediated programmed cell death]
Show all
 1215 aa
131.4 kDa 		No 0
HDAC6-007
ENSP00000365831
ENST00000376643
A6NDI8 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 210 aa
23.4 kDa 		No 0
HDAC6-015
ENSP00000402189
ENST00000426196
E7EPS2 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 269 aa
30.3 kDa 		No 0
HDAC6-016
ENSP00000397697
ENST00000430858
H7C0Z9 [Direct mapping]
Histone deacetylase 6
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 84 aa
8.7 kDa 		No 0
HDAC6-017
ENSP00000365804
ENST00000376619
Q9UBN7 [Direct mapping]
Histone deacetylase 6
A0A024QZ26 [Target identity:100%; Query identity:100%]
Histone deacetylase 6, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0001047 [core promoter binding]
GO:0003779 [actin binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005875 [microtubule associated complex]
GO:0005901 [caveola]
GO:0006351 [transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0006515 [misfolded or incompletely synthesized protein catabolic process]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0008013 [beta-catenin binding]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0009636 [response to toxic substance]
GO:0009967 [positive regulation of signal transduction]
GO:0010033 [response to organic substance]
GO:0010469 [regulation of receptor activity]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010727 [negative regulation of hydrogen peroxide metabolic process]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0016234 [inclusion body]
GO:0016235 [aggresome]
GO:0016236 [macroautophagy]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0030286 [dynein complex]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031252 [cell leading edge]
GO:0031593 [polyubiquitin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032418 [lysosome localization]
GO:0034605 [cellular response to heat]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035967 [cellular response to topologically incorrect protein]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042826 [histone deacetylase binding]
GO:0042903 [tubulin deacetylase activity]
GO:0043014 [alpha-tubulin binding]
GO:0043204 [perikaryon]
GO:0043242 [negative regulation of protein complex disassembly]
GO:0045861 [negative regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051354 [negative regulation of oxidoreductase activity]
GO:0051787 [misfolded protein binding]
GO:0051788 [response to misfolded protein]
GO:0051879 [Hsp90 protein binding]
GO:0060632 [regulation of microtubule-based movement]
GO:0060765 [regulation of androgen receptor signaling pathway]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070840 [dynein complex binding]
GO:0070842 [aggresome assembly]
GO:0070845 [polyubiquitinated misfolded protein transport]
GO:0070846 [Hsp90 deacetylation]
GO:0070848 [response to growth factor]
GO:0070932 [histone H3 deacetylation]
GO:0090035 [positive regulation of chaperone-mediated protein complex assembly]
GO:0090042 [tubulin deacetylation]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901300 [positive regulation of hydrogen peroxide-mediated programmed cell death]
Show all
 1215 aa
131.4 kDa 		No 0
HDAC6-020
ENSP00000392815
ENST00000423941
C9J172 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 142 aa
15.9 kDa 		No 0
HDAC6-021
ENSP00000403370
ENST00000438518
C9JEF4 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5.6 kDa 		No 0
HDAC6-023
ENSP00000365795
ENST00000376610
A6NDI8 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 210 aa
23.4 kDa 		No 0
HDAC6-028
ENSP00000393916
ENST00000441703
E9PEH1 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 161 aa
18.2 kDa 		No 0
HDAC6-030
ENSP00000402751
ENST00000443563
E7EP63 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 167 aa
18.9 kDa 		No 0
HDAC6-031
ENSP00000394377
ENST00000440653
E7ER52 [Direct mapping]
Histone deacetylase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 171 aa
19.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.