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Malignant cells displayed weak to moderate cytoplasmic and/or nuclear positivity. A rare case each of malignant carcinoid, melanoma, urothelial cancer and hepatocellular carcinoma were strongly stained.
GENE INFORMATION
Gene name
CDC6 (HGNC Symbol)
Synonyms
CDC18L
Description
Cell division cycle 6 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Q99741 [Direct mapping] Cell division control protein 6 homolog A0A024R1S2 [Target identity:100%; Query identity:100%] CDC6 cell division cycle 6 homolog (S. cerevisiae), isoform CRA_a
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Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000076 [DNA replication checkpoint] GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0000278 [mitotic cell cycle] GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006270 [DNA replication initiation] GO:0007067 [mitotic nuclear division] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0008156 [negative regulation of DNA replication] GO:0008285 [negative regulation of cell proliferation] GO:0019900 [kinase binding] GO:0030071 [regulation of mitotic metaphase/anaphase transition] GO:0032467 [positive regulation of cytokinesis] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0048146 [positive regulation of fibroblast proliferation] GO:0051233 [spindle midzone] GO:0051301 [cell division] GO:0051984 [positive regulation of chromosome segregation] GO:1904117 [cellular response to vasopressin] GO:1904385 [cellular response to angiotensin]