Expression of SUCO in cancer - Summary - The Human Protein Atlas

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SUCO

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SUCO
Gene description	SUN domain containing ossification factor
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a membranous pattern in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA047251
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA047251

GENE INFORMATION
Gene name	SUCO (HGNC Symbol)
Synonyms	C1orf9, CH1, OPT, SLP1
Description	SUN domain containing ossification factor (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q24.3
Chromosome location (bp)	172532349 - 172611833
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000094975 (version 83.38)
Entrez gene	51430
UniProt	Q9UBS9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBS9
Antibodypedia	SUCO antibodies

PROTEIN BROWSER

SUCO-001	SUCO-002	SUCO-004	SUCO-201	SUCO-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SUCO-001 ENSP00000263688 ENST00000263688	Q9UBS9 [Direct mapping] SUN domain-containing ossification factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0005791 [rough endoplasmic reticulum] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030867 [rough endoplasmic reticulum membrane] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0046850 [regulation of bone remodeling] Show all	1254 aa 139.4 kDa	Yes	1
SUCO-002 ENSP00000356696 ENST00000367723	Q9UBS9 [Direct mapping] SUN domain-containing ossification factor A0A024R929 [Target identity:100%; Query identity:100%] Chromosome 1 open reading frame 9, isoform CRA_d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0005791 [rough endoplasmic reticulum] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030867 [rough endoplasmic reticulum membrane] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0046850 [regulation of bone remodeling] Show all	1405 aa 156.4 kDa	No	3
SUCO-004 ENSP00000476704 ENST00000610051	B4DYM4 [Direct mapping] SUN domain-containing ossification factor; cDNA FLJ60972 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		883 aa 98.3 kDa	Yes	1
SUCO-201 ENSP00000477484 ENST00000608151	Q9UBS9 [Direct mapping] SUN domain-containing ossification factor A0A024R929 [Target identity:100%; Query identity:100%] Chromosome 1 open reading frame 9, isoform CRA_d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0005791 [rough endoplasmic reticulum] GO:0007275 [multicellular organismal development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030867 [rough endoplasmic reticulum membrane] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0046850 [regulation of bone remodeling] Show all	1405 aa 156.4 kDa	No	3
SUCO-202 ENSP00000479061 ENST00000616058	A0A087WV04 [Direct mapping] SUN domain-containing ossification factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		691 aa 77.4 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.