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Malignant cells showed moderate to strong cytoplasmic immunoreactivity with a granular pattern.
GENE INFORMATION
Gene name
MAP3K1 (HGNC Symbol)
Synonyms
MAPKKK1, MEKK, MEKK1
Description
Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]