Expression of HOOK2 in cancer - Summary - The Human Protein Atlas

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HOOK2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HOOK2
Gene description	Hook microtubule-tethering protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA043519 , HPA050351
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (unfavourable) and renal cancer (favourable).
Prostate cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043519	HPA050351

GENE INFORMATION
Gene name	HOOK2 (HGNC Symbol)
Synonyms	HK2
Description	Hook microtubule-tethering protein 2 (HGNC Symbol)
Entrez gene summary	Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Chromosome	19
Cytoband	p13.13
Chromosome location (bp)	12763003 - 12872740
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000095066 (version 83.38)
Entrez gene	29911
UniProt	Q96ED9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96ED9
Antibodypedia	HOOK2 antibodies

PROTEIN BROWSER

HOOK2-001	HOOK2-002	HOOK2-005	HOOK2-008	HOOK2-010	HOOK2-012	HOOK2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOOK2-001 ENSP00000264827 ENST00000264827	Q96ED9 [Direct mapping] Protein Hook homolog 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0006897 [endocytosis] GO:0007032 [endosome organization] GO:0007040 [lysosome organization] GO:0008333 [endosome to lysosome transport] GO:0015031 [protein transport] GO:0030897 [HOPS complex] GO:0042802 [identical protein binding] GO:0045022 [early endosome to late endosome transport] GO:0070695 [FHF complex] Show all	717 aa 83 kDa	No	0
HOOK2-002 ENSP00000380785 ENST00000397668	Q96ED9 [Direct mapping] Protein Hook homolog 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0006897 [endocytosis] GO:0007032 [endosome organization] GO:0007040 [lysosome organization] GO:0008333 [endosome to lysosome transport] GO:0015031 [protein transport] GO:0030897 [HOPS complex] GO:0042802 [identical protein binding] GO:0045022 [early endosome to late endosome transport] GO:0070695 [FHF complex] Show all	719 aa 83.2 kDa	No	0
HOOK2-005 ENSP00000465042 ENST00000587178	K7EJ65 [Direct mapping] Protein Hook homolog 2 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		209 aa 23.3 kDa	No	0
HOOK2-008 ENSP00000465023 ENST00000592079	K7EJ48 [Direct mapping] Protein Hook homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		226 aa 25.8 kDa	No	0
HOOK2-010 ENSP00000466616 ENST00000590839	K7EMR5 [Direct mapping] Protein Hook homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		157 aa 17.8 kDa	No	0
HOOK2-012 ENSP00000467097 ENST00000589400	K7ENU5 [Direct mapping] Protein Hook homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		270 aa 31 kDa	No	0
HOOK2-015 ENSP00000466497 ENST00000588052	K7EMG7 [Direct mapping] Protein Hook homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 14.6 kDa	No	0

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The Human Protein Atlas

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