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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HOOK2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HOOK2

Gene description

Hook microtubule-tethering protein 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA043519 , HPA050351
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in prostate cancer (unfavourable) and renal cancer (favourable).
Prostate cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA043519
HPA050351

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate cytoplasmic and occasional nuclear or membranous positivity. Several cases of prostate cancers along with a few cases of colorectal, endometrial and pancreatic cancers showed strong staining. Several renal cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Colorectal cancers along with a few cases of ovarian cancers showed strong membranous staining. A few cases of duct carcinomas of breast, squamous cell carcinomas of cervix, head and neck cancers along with prostate cancers showed moderate cytoplasmic positivity. Several cases of melanomas showed weak to moderate nuclear staining. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

HOOK2 (HGNC Symbol)

Synonyms

HK2

Description

Hook microtubule-tethering protein 2 (HGNC Symbol)

Entrez gene summary

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

Chromosome

19

Cytoband

p13.13

Chromosome location (bp)

12763003 - 12872740

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000095066 (version 83.38)

Entrez gene

29911

UniProt

Q96ED9 (UniProt - Evidence at protein level)

neXtProt

NX_Q96ED9

Antibodypedia

HOOK2 antibodies

PROTEIN BROWSER

HOOK2-001
HOOK2-002
HOOK2-005
HOOK2-008
HOOK2-010
HOOK2-012
HOOK2-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HOOK2-001
ENSP00000264827
ENST00000264827
Q96ED9 [Direct mapping]
Protein Hook homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005874 [microtubule]
GO:0006897 [endocytosis]
GO:0007032 [endosome organization]
GO:0007040 [lysosome organization]
GO:0008333 [endosome to lysosome transport]
GO:0015031 [protein transport]
GO:0030897 [HOPS complex]
GO:0042802 [identical protein binding]
GO:0045022 [early endosome to late endosome transport]
GO:0070695 [FHF complex]
Show all
717 aa
83 kDa
No 0
HOOK2-002
ENSP00000380785
ENST00000397668
Q96ED9 [Direct mapping]
Protein Hook homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005874 [microtubule]
GO:0006897 [endocytosis]
GO:0007032 [endosome organization]
GO:0007040 [lysosome organization]
GO:0008333 [endosome to lysosome transport]
GO:0015031 [protein transport]
GO:0030897 [HOPS complex]
GO:0042802 [identical protein binding]
GO:0045022 [early endosome to late endosome transport]
GO:0070695 [FHF complex]
Show all
719 aa
83.2 kDa
No 0
HOOK2-005
ENSP00000465042
ENST00000587178
K7EJ65 [Direct mapping]
Protein Hook homolog 2
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
209 aa
23.3 kDa
No 0
HOOK2-008
ENSP00000465023
ENST00000592079
K7EJ48 [Direct mapping]
Protein Hook homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
226 aa
25.8 kDa
No 0
HOOK2-010
ENSP00000466616
ENST00000590839
K7EMR5 [Direct mapping]
Protein Hook homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
157 aa
17.8 kDa
No 0
HOOK2-012
ENSP00000467097
ENST00000589400
K7ENU5 [Direct mapping]
Protein Hook homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
270 aa
31 kDa
No 0
HOOK2-015
ENSP00000466497
ENST00000588052
K7EMG7 [Direct mapping]
Protein Hook homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
128 aa
14.6 kDa
No 0

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