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PSMD5

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GENERAL INFORMATION

Gene name

 PSMD5

Gene description

 Proteasome 26S subunit, non-ATPase 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the nucleus.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Additional location

 In addition localized to the Nucleus (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA003216
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the nucleus.

Main location

 Cytosol (approved)

Additional location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA003216 A-431 Nucleus Spatial
Cytosol Spatial
HPA003216 U-2 OS Nucleus Spatial
Cytosol Spatial
HPA003216 U-251 MG Nucleus Spatial
Cytosol Spatial

GENE INFORMATION

Gene name

 PSMD5 (HGNC Symbol)

Synonyms

 KIAA0072, S5B

Description

 Proteasome 26S subunit, non-ATPase 5 (HGNC Symbol)

Entrez gene summary

 The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]

Chromosome

 9

Cytoband

 q33.2

Chromosome location (bp)

 120815496 - 120842984

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000095261 (version 83.38)

Entrez gene

 5711

UniProt

 Q16401 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16401

Antibodypedia

 PSMD5 antibodies

PROTEIN BROWSER
PSMD5-001
PSMD5-003
PSMD5-007
PSMD5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSMD5-001
ENSP00000210313
ENST00000210313
Q16401 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 5
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0022624 [proteasome accessory complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043248 [proteasome assembly]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070682 [proteasome regulatory particle assembly]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 504 aa
56.2 kDa 		No 0
PSMD5-003
ENSP00000363030
ENST00000373920
Q4VXH0 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043248 [proteasome assembly]
Show all
 113 aa
12.9 kDa 		No 0
PSMD5-007
ENSP00000363011
ENST00000373904
Q16401 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 5
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0022624 [proteasome accessory complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043248 [proteasome assembly]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070682 [proteasome regulatory particle assembly]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 461 aa
51.3 kDa 		No 0
PSMD5-201
ENSP00000487480
ENST00000625444
F2Z3J2 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 5
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043248 [proteasome assembly]
Show all
 72 aa
8.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.