Cell atlas - PTGS1 - The Human Protein Atlas

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PTGS1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

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GENERAL INFORMATION
Gene name	PTGS1
Gene description	Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Protein class	Cancer-related genes Enzymes FDA approved drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to vesicles.
RNA cell category	Cell line enhanced (HMC-1, BJ hTERT+, BJ)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)
Additional location	In addition localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA002834
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, BJ hTERT+, BJ) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to vesicles.

Main location

Golgi apparatus (supported)

Additional location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002834	BJ	Golgi apparatus
	HPA002834	U-2 OS	Golgi apparatus
	HPA002834	U-2 OS	Vesicles
	HPA002834	U-251 MG	Golgi apparatus
	HPA002834	U-251 MG	Vesicles

GENE INFORMATION
Gene name	PTGS1 (HGNC Symbol)
Synonyms	COX1, PGHS-1, PTGHS
Description	Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (HGNC Symbol)
Entrez gene summary	This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	9
Cytoband	q33.2
Chromosome location (bp)	122370530 - 122395703
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000095303 (version 83.38)
Entrez gene	5742
UniProt	P23219 (UniProt - Evidence at protein level)
neXtProt	NX_P23219
Antibodypedia	PTGS1 antibodies

PROTEIN BROWSER

PTGS1-001	PTGS1-002	PTGS1-003	PTGS1-201	PTGS1-202	PTGS1-203	PTGS1-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTGS1-001 ENSP00000354612 ENST00000362012	P23219 [Direct mapping] Prostaglandin G/H synthase 1 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001516 [prostaglandin biosynthetic process] GO:0001750 [photoreceptor outer segment] GO:0004601 [peroxidase activity] GO:0004666 [prostaglandin-endoperoxide synthase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006693 [prostaglandin metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0007568 [aging] GO:0007612 [learning] GO:0007613 [memory] GO:0008217 [regulation of blood pressure] GO:0008289 [lipid binding] GO:0010243 [response to organonitrogen compound] GO:0010700 [negative regulation of norepinephrine secretion] GO:0019233 [sensory perception of pain] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0032811 [negative regulation of epinephrine secretion] GO:0035633 [maintenance of blood-brain barrier] GO:0042127 [regulation of cell proliferation] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0045907 [positive regulation of vasoconstriction] GO:0045987 [positive regulation of smooth muscle contraction] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0051412 [response to corticosterone] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0070542 [response to fatty acid] Show all	599 aa 68.7 kDa	Yes	0
PTGS1-002 ENSP00000223423 ENST00000223423	P23219 [Direct mapping] Prostaglandin G/H synthase 1 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001516 [prostaglandin biosynthetic process] GO:0004601 [peroxidase activity] GO:0004666 [prostaglandin-endoperoxide synthase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0008217 [regulation of blood pressure] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	562 aa 64.5 kDa	Yes	0
PTGS1-003 ENSP00000411606 ENST00000426608	X6RJD6 [Direct mapping] Prostaglandin G/H synthase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004601 [peroxidase activity] GO:0004666 [prostaglandin-endoperoxide synthase activity] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0008217 [regulation of blood pressure] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	156 aa 18 kDa	Yes	0
PTGS1-201 ENSP00000362802 ENST00000373698	P23219 [Direct mapping] Prostaglandin G/H synthase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001516 [prostaglandin biosynthetic process] GO:0004601 [peroxidase activity] GO:0004666 [prostaglandin-endoperoxide synthase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0008217 [regulation of blood pressure] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	490 aa 56.1 kDa	No	0
PTGS1-202 ENSP00000437709 ENST00000540753	P23219 [Direct mapping] Prostaglandin G/H synthase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001516 [prostaglandin biosynthetic process] GO:0004601 [peroxidase activity] GO:0004666 [prostaglandin-endoperoxide synthase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0008217 [regulation of blood pressure] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	537 aa 61.9 kDa	No	0
PTGS1-203 ENSP00000484800 ENST00000614910	A0A087X296 [Direct mapping] Prostaglandin G/H synthase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004601 [peroxidase activity] GO:0004666 [prostaglandin-endoperoxide synthase activity] GO:0005515 [protein binding] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0008217 [regulation of blood pressure] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	551 aa 63.3 kDa	Yes	0
PTGS1-204 ENSP00000483540 ENST00000619306	P23219 [Direct mapping] Prostaglandin G/H synthase 1 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001516 [prostaglandin biosynthetic process] GO:0004601 [peroxidase activity] GO:0004666 [prostaglandin-endoperoxide synthase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0008217 [regulation of blood pressure] GO:0019369 [arachidonic acid metabolic process] GO:0019371 [cyclooxygenase pathway] GO:0020037 [heme binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	630 aa 72 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.