Expression of TBC1D2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TBC1D2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TBC1D2
Gene description	TBC1 domain family, member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A-431, HaCaT)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images. Subcellular location is contradicted by limited external data.
Reliability score	Uncertain based on 1 antibody. HPA030871
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable) and testis cancer (unfavourable).
Head and neck cancer p<0.001 Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030871

GENE INFORMATION
Gene name	TBC1D2 (HGNC Symbol)
Synonyms	Armus, PARIS1, TBC1D2A
Description	TBC1 domain family, member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q22.33
Chromosome location (bp)	98198999 - 98255721
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000095383 (version 83.38)
Entrez gene	55357
UniProt	Q9BYX2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYX2
Antibodypedia	TBC1D2 antibodies

PROTEIN BROWSER

TBC1D2-001	TBC1D2-002	TBC1D2-003	TBC1D2-006	TBC1D2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBC1D2-001 ENSP00000364205 ENST00000375064	Q9BYX2 [Direct mapping] TBC1 domain family member 2A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030054 [cell junction] GO:0031410 [cytoplasmic vesicle] GO:0043547 [positive regulation of GTPase activity] GO:0045296 [cadherin binding] Show all	860 aa 97.3 kDa	No	0
TBC1D2-002 ENSP00000364207 ENST00000375066	Q9BYX2 [Direct mapping] TBC1 domain family member 2A Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030054 [cell junction] GO:0031410 [cytoplasmic vesicle] GO:0043547 [positive regulation of GTPase activity] GO:0045296 [cadherin binding] Show all	917 aa 104.1 kDa	No	0
TBC1D2-003 ENSP00000341567 ENST00000342112	Q9BYX2 [Direct mapping] TBC1 domain family member 2A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030054 [cell junction] GO:0031410 [cytoplasmic vesicle] GO:0043547 [positive regulation of GTPase activity] GO:0045296 [cadherin binding] Show all	710 aa 81.7 kDa	No	0
TBC1D2-006 ENSP00000364203 ENST00000375063	Q9BYX2 [Direct mapping] TBC1 domain family member 2A A0A024R166 [Target identity:100%; Query identity:100%] TBC1 domain family, member 2, isoform CRA_f Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030054 [cell junction] GO:0031410 [cytoplasmic vesicle] GO:0043547 [positive regulation of GTPase activity] GO:0045296 [cadherin binding] Show all	468 aa 54.4 kDa	No	0
TBC1D2-201 ENSP00000481721 ENST00000465784	Q9BYX2 [Direct mapping] TBC1 domain family member 2A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030054 [cell junction] GO:0031410 [cytoplasmic vesicle] GO:0043547 [positive regulation of GTPase activity] GO:0045296 [cadherin binding] Show all	928 aa 105.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.