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SORBS1

GENERAL INFORMATION

Gene name

 SORBS1

Gene description

 Sorbin and SH3 domain containing 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CACO-2, HMC-1, SK-MEL-30)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic and membrane expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA027559 , HPA043084
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027559
HPA043084

GENE INFORMATION

Gene name

 SORBS1 (HGNC Symbol)

Synonyms

 CAP, FLJ12406, KIAA1296, ponsin, SH3D5, sh3p12

Description

 Sorbin and SH3 domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

 10

Cytoband

 q24.1

Chromosome location (bp)

 95311771 - 95561414

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000095637 (version 83.38)

Entrez gene

 10580

UniProt

 Q9BX66 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BX66

Antibodypedia

 SORBS1 antibodies

PROTEIN BROWSER
«
SORBS1-001
SORBS1-002
SORBS1-004
SORBS1-005
SORBS1-006
SORBS1-007
SORBS1-008
SORBS1-009
SORBS1-011
SORBS1-015
SORBS1-016
SORBS1-017
SORBS1-019
SORBS1-020
SORBS1-201
SORBS1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SORBS1-001
ENSP00000302556
ENST00000306402
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 781 aa
87.2 kDa 		No 0
SORBS1-002
ENSP00000360295
ENST00000371249
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 816 aa
90.2 kDa 		No 0
SORBS1-004
ENSP00000355136
ENST00000361941
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 1292 aa
142.5 kDa 		No 0
SORBS1-005
ENSP00000277982
ENST00000277982
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 1151 aa
127.3 kDa 		No 0
SORBS1-006
ENSP00000360291
ENST00000371245
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 905 aa
101.1 kDa 		No 0
SORBS1-007
ENSP00000360285
ENST00000371241
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 684 aa
76.6 kDa 		No 0
SORBS1-008
ENSP00000277984
ENST00000354106
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 1004 aa
111.8 kDa 		No 0
SORBS1-009
ENSP00000360283
ENST00000371239
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 811 aa
91.1 kDa 		No 0
SORBS1-011
ENSP00000474932
ENST00000492542
S4R406 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 146 aa
15.1 kDa 		No 0
SORBS1-015
ENSP00000360271
ENST00000371227
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 1266 aa
139.4 kDa 		No 0
SORBS1-016
ENSP00000473813
ENST00000486141
S4R303 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 192 aa
20.6 kDa 		No 0
SORBS1-017
ENSP00000475901
ENST00000607232
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 1294 aa
143.7 kDa 		No 0
SORBS1-019
ENSP00000360272
ENST00000371228
Q5T925 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 186 aa
21.1 kDa 		No 0
SORBS1-020
ENSP00000489022
ENST00000634504
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 507 aa
57.9 kDa 		No 0
SORBS1-201
ENSP00000360292
ENST00000371246
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 1151 aa
127.3 kDa 		No 0
SORBS1-202
ENSP00000360293
ENST00000371247
Q9BX66 [Direct mapping]
Sorbin and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005924 [cell-substrate adherens junction]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0007160 [cell-matrix adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0015758 [glucose transport]
GO:0016363 [nuclear matrix]
GO:0019901 [protein kinase binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0043149 [stress fiber assembly]
GO:0045121 [membrane raft]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0048041 [focal adhesion assembly]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
Show all
 1292 aa
142.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.