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BAMBI

GENERAL INFORMATION

Gene name

 BAMBI

Gene description

 BMP and activin membrane-bound inhibitor

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CACO-2, SK-MEL-30)
HPA (normal tissue):Tissue enhanced (ovary)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic positivity in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA010866
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010866

GENE INFORMATION

Gene name

 BAMBI (HGNC Symbol)

Synonyms

 NMA

Description

 BMP and activin membrane-bound inhibitor (HGNC Symbol)

Entrez gene summary

 This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p12.1

Chromosome location (bp)

 28677342 - 28682939

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000095739 (version 83.38)

Entrez gene

 25805

UniProt

 Q13145 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13145

Antibodypedia

 BAMBI antibodies

PROTEIN BROWSER
BAMBI-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BAMBI-001
ENSP00000364683
ENST00000375533
Q13145 [Direct mapping]
BMP and activin membrane-bound inhibitor homolog
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
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GO:0005109 [frizzled binding]
GO:0005114 [type II transforming growth factor beta receptor binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0032092 [positive regulation of protein binding]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
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 260 aa
29.1 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.