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SRPK1

GENERAL INFORMATION

Gene name

 SRPK1

Gene description

 SRSF protein kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiqtuious cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA016431
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016431

GENE INFORMATION

Gene name

 SRPK1 (HGNC Symbol)

Synonyms

 SFRSK1

Description

 SRSF protein kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 35832966 - 35921342

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000096063 (version 83.38)

Entrez gene

 6732

UniProt

 Q96SB4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96SB4

Antibodypedia

 SRPK1 antibodies

PROTEIN BROWSER
SRPK1-001
SRPK1-002
SRPK1-004
SRPK1-005
SRPK1-007
SRPK1-010
SRPK1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRPK1-001
ENSP00000362931
ENST00000373825
Q96SB4 [Direct mapping]
SRSF protein kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0007059 [chromosome segregation]
GO:0008380 [RNA splicing]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0035092 [sperm chromatin condensation]
GO:0035556 [intracellular signal transduction]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0048024 [regulation of mRNA splicing, via spliceosome]
GO:0050684 [regulation of mRNA processing]
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 655 aa
74.3 kDa 		No 0
SRPK1-002
ENSP00000391069
ENST00000423325
Q96SB4 [Direct mapping]
SRSF protein kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0007059 [chromosome segregation]
GO:0008380 [RNA splicing]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0035092 [sperm chromatin condensation]
GO:0035556 [intracellular signal transduction]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0048024 [regulation of mRNA splicing, via spliceosome]
GO:0050684 [regulation of mRNA processing]
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 639 aa
72.4 kDa 		No 0
SRPK1-004
ENSP00000424068
ENST00000512445
D6RBM8 [Direct mapping]
SRSF protein kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 155 aa
17.5 kDa 		No 0
SRPK1-005
ENSP00000354674
ENST00000361690
H3BLV9 [Direct mapping]
SRSF protein kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
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 671 aa
76 kDa 		No 0
SRPK1-007
ENSP00000424323
ENST00000507909
D6RB98 [Direct mapping]
SRSF protein kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 118 aa
12.7 kDa 		No 0
SRPK1-010
ENSP00000424170
ENST00000510290
D6RBF8 [Direct mapping]
SRSF protein kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
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 146 aa
16.6 kDa 		No 0
SRPK1-201
ENSP00000362928
ENST00000373822
Q5R363 [Direct mapping]
SRSF protein kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
Show all
 826 aa
92.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.