Expression of PGC in cancer - Summary - The Human Protein Atlas

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PGC

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PGC
Gene description	Progastricsin (pepsinogen C)
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (stomach cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in gastric glands.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA031717 , HPA031718
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031717	HPA031718

GENE INFORMATION
Gene name	PGC
Synonyms
Description	Progastricsin (pepsinogen C) (HGNC Symbol)
Entrez gene summary	This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	41736711 - 41754109
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000096088 (version 83.38)
Entrez gene	5225
UniProt	P20142 (UniProt - Evidence at protein level)
neXtProt	NX_P20142
Antibodypedia	PGC antibodies

PROTEIN BROWSER

PGC-001	PGC-003	PGC-004	PGC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGC-001 ENSP00000362116 ENST00000373025	P20142 [Direct mapping] Gastricsin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002803 [positive regulation of antibacterial peptide production] GO:0004190 [aspartic-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0030163 [protein catabolic process] GO:0070062 [extracellular exosome] Show all	388 aa 42.4 kDa	Yes	0
PGC-003 ENSP00000349094 ENST00000356667	Q4VXA6 [Direct mapping] Gastricsin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	140 aa 15.7 kDa	Yes	0
PGC-004 ENSP00000399429 ENST00000415707	A2A3L9 [Direct mapping] Gastricsin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	86 aa 10 kDa	No	0
PGC-201 ENSP00000405094 ENST00000425343	P20142 [Direct mapping] Gastricsin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002803 [positive regulation of antibacterial peptide production] GO:0004190 [aspartic-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0030163 [protein catabolic process] GO:0070062 [extracellular exosome] Show all	315 aa 34.2 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.