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HSP90AB1

GENERAL INFORMATION

Gene name

 HSP90AB1

Gene description

 Heat shock protein 90kDa alpha (cytosolic), class B member 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB005230
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable) and renal cancer (unfavourable).
Ovarian cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB005230

GENE INFORMATION

Gene name

 HSP90AB1 (HGNC Symbol)

Synonyms

 HSPC2, HSPCB

Description

 Heat shock protein 90kDa alpha (cytosolic), class B member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 44246166 - 44253888

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000096384 (version 83.38)

Entrez gene

 3326

UniProt

 P08238 (UniProt - Evidence at protein level)

neXtProt

 NX_P08238

Antibodypedia

 HSP90AB1 antibodies

PROTEIN BROWSER
HSP90AB1-003
HSP90AB1-004
HSP90AB1-005
HSP90AB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSP90AB1-003
ENSP00000360709
ENST00000371646
P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A0A024RD80 [Target identity:100%; Query identity:100%]
Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0016020 [membrane]
GO:0019062 [virion attachment to host cell]
GO:0019900 [kinase binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0051082 [unfolded protein binding]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0097435 [fibril organization]
GO:1900034 [regulation of cellular response to heat]
Show all
 724 aa
83.3 kDa 		No 0
HSP90AB1-004
ENSP00000325875
ENST00000353801
P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A0A024RD80 [Target identity:100%; Query identity:100%]
Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0016020 [membrane]
GO:0019062 [virion attachment to host cell]
GO:0019900 [kinase binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0051082 [unfolded protein binding]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0097435 [fibril organization]
GO:1900034 [regulation of cellular response to heat]
Show all
 724 aa
83.3 kDa 		No 0
HSP90AB1-005
ENSP00000360609
ENST00000371554
P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A0A024RD80 [Target identity:100%; Query identity:100%]
Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001890 [placenta development]
GO:0002134 [UTP binding]
GO:0002135 [CTP binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0009651 [response to salt stress]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016234 [inclusion body]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017098 [sulfonylurea receptor binding]
GO:0019062 [virion attachment to host cell]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0031526 [brush border membrane]
GO:0032092 [positive regulation of protein binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032564 [dATP binding]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0034605 [cellular response to heat]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044325 [ion channel binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045793 [positive regulation of cell size]
GO:0051082 [unfolded protein binding]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0071353 [cellular response to interleukin-4]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0097435 [fibril organization]
GO:1900034 [regulation of cellular response to heat]
Show all
 724 aa
83.3 kDa 		No 0
HSP90AB1-201
ENSP00000481908
ENST00000620073
P08238 [Direct mapping]
Heat shock protein HSP 90-beta
A0A024RD80 [Target identity:100%; Query identity:100%]
Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006950 [response to stress]
GO:0006986 [response to unfolded protein]
GO:0007411 [axon guidance]
GO:0008180 [COP9 signalosome]
GO:0016020 [membrane]
GO:0019062 [virion attachment to host cell]
GO:0019900 [kinase binding]
GO:0023026 [MHC class II protein complex binding]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034605 [cellular response to heat]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042470 [melanosome]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0051082 [unfolded protein binding]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0097435 [fibril organization]
GO:1900034 [regulation of cellular response to heat]
Show all
 724 aa
83.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.