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Strong nuclear immunoreactivity, often accompanied with weak to moderate cytoplasmic staining, was observed in cervical and ovarian cancers and in embryonal carcinomas of testis. In squamous cell carcinomas, keratinized parts were strongly stained. Some endometrial cancers displayed additional membranous positivity. Remaining tumors were weakly or moderately stained in cytoplasm or nuclei.
Most cancer tissues were negative or showed weak nuclear immunoreactivity. Strong staining was observed in testicular cancers and in rare cases of head & neck-, lung- and liver cancers.
GENE INFORMATION
Gene name
SIRT1 (HGNC Symbol)
Synonyms
SIR2L1
Description
Sirtuin 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]