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IL12RB1

GENERAL INFORMATION

Gene name

 IL12RB1

Gene description

 Interleukin 12 receptor, beta 1

Protein class

 CD markers
Disease related genes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HDLM-2, Karpas-707)
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and cervical cancer (favourable).
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 IL12RB1 (HGNC Symbol)

Synonyms

 CD212, IL12RB

Description

 Interleukin 12 receptor, beta 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 18058995 - 18098944

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000096996 (version 83.38)

Entrez gene

 3594

UniProt

 P42701 (UniProt - Evidence at protein level)

neXtProt

 NX_P42701

Antibodypedia

 IL12RB1 antibodies

PROTEIN BROWSER
IL12RB1-001
IL12RB1-002
IL12RB1-003
IL12RB1-005
IL12RB1-006
IL12RB1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL12RB1-001
ENSP00000472165
ENST00000593993
P42701 [Direct mapping]
Interleukin-12 receptor subunit beta-1
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0001916 [positive regulation of T cell mediated cytotoxicity]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002827 [positive regulation of T-helper 1 type immune response]
GO:0004896 [cytokine receptor activity]
GO:0005143 [interleukin-12 receptor binding]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0016517 [interleukin-12 receptor activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0038155 [interleukin-23-mediated signaling pathway]
GO:0042019 [interleukin-23 binding]
GO:0042020 [interleukin-23 receptor activity]
GO:0042022 [interleukin-12 receptor complex]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0071346 [cellular response to interferon-gamma]
GO:0072536 [interleukin-23 receptor complex]
GO:2000318 [positive regulation of T-helper 17 type immune response]
GO:2000330 [positive regulation of T-helper 17 cell lineage commitment]
Show all
 662 aa
73.1 kDa 		Yes 1
IL12RB1-002
ENSP00000470788
ENST00000600835
P42701 [Direct mapping]
Interleukin-12 receptor subunit beta-1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0001916 [positive regulation of T cell mediated cytotoxicity]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002827 [positive regulation of T-helper 1 type immune response]
GO:0004896 [cytokine receptor activity]
GO:0005143 [interleukin-12 receptor binding]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0009897 [external side of plasma membrane]
GO:0016020 [membrane]
GO:0016517 [interleukin-12 receptor activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019955 [cytokine binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0038155 [interleukin-23-mediated signaling pathway]
GO:0042019 [interleukin-23 binding]
GO:0042020 [interleukin-23 receptor activity]
GO:0042022 [interleukin-12 receptor complex]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0071346 [cellular response to interferon-gamma]
GO:0072536 [interleukin-23 receptor complex]
GO:2000318 [positive regulation of T-helper 17 type immune response]
GO:2000330 [positive regulation of T-helper 17 cell lineage commitment]
Show all
 662 aa
73.1 kDa 		Yes 1
IL12RB1-003
ENSP00000314425
ENST00000322153
P42701 [Direct mapping]
Interleukin-12 receptor subunit beta-1
Show all
CD markers
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0001916 [positive regulation of T cell mediated cytotoxicity]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0002827 [positive regulation of T-helper 1 type immune response]
GO:0004896 [cytokine receptor activity]
GO:0005143 [interleukin-12 receptor binding]
GO:0007165 [signal transduction]
GO:0016517 [interleukin-12 receptor activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0038155 [interleukin-23-mediated signaling pathway]
GO:0042019 [interleukin-23 binding]
GO:0042020 [interleukin-23 receptor activity]
GO:0042022 [interleukin-12 receptor complex]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043382 [positive regulation of memory T cell differentiation]
GO:0071346 [cellular response to interferon-gamma]
GO:0072536 [interleukin-23 receptor complex]
GO:2000318 [positive regulation of T-helper 17 type immune response]
GO:2000330 [positive regulation of T-helper 17 cell lineage commitment]
Show all
 381 aa
42.4 kDa 		Yes 0
IL12RB1-005
ENSP00000473051
ENST00000594176
M0R382 [Direct mapping]
Interleukin-12 receptor subunit beta-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 51 aa
5.6 kDa 		Yes 0
IL12RB1-006
ENSP00000468831
ENST00000598019
M0QX06 [Direct mapping]
Interleukin-12 receptor subunit beta-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 67 aa
7.7 kDa 		Yes 0
IL12RB1-008
ENSP00000403103
ENST00000430026
X6RGM1 [Direct mapping]
Interleukin-12 receptor subunit beta-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 118 aa
13 kDa 		Yes 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.