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This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0000724 [double-strand break repair via homologous recombination] GO:0001934 [positive regulation of protein phosphorylation] GO:0003677 [DNA binding] GO:0003785 [actin monomer binding] GO:0004515 [nicotinate-nucleotide adenylyltransferase activity] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006298 [mismatch repair] GO:0006302 [double-strand break repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006914 [autophagy] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0006979 [response to oxidative stress] GO:0007050 [cell cycle arrest] GO:0007067 [mitotic nuclear division] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008022 [protein C-terminus binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010506 [regulation of autophagy] GO:0015629 [actin cytoskeleton] GO:0016477 [cell migration] GO:0017124 [SH3 domain binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019905 [syntaxin binding] GO:0030036 [actin cytoskeleton organization] GO:0030100 [regulation of endocytosis] GO:0030145 [manganese ion binding] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0030516 [regulation of axon extension] GO:0031113 [regulation of microtubule polymerization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031965 [nuclear membrane] GO:0032956 [regulation of actin cytoskeleton organization] GO:0034599 [cellular response to oxidative stress] GO:0035791 [platelet-derived growth factor receptor-beta signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042692 [muscle cell differentiation] GO:0042770 [signal transduction in response to DNA damage] GO:0043065 [positive regulation of apoptotic process] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051019 [mitogen-activated protein kinase binding] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051353 [positive regulation of oxidoreductase activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051882 [mitochondrial depolarization] GO:0070064 [proline-rich region binding] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:1900275 [negative regulation of phospholipase C activity] GO:1903351 [cellular response to dopamine] GO:1904528 [positive regulation of microtubule binding] GO:1904531 [positive regulation of actin filament binding] GO:2000145 [regulation of cell motility] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2001020 [regulation of response to DNA damage stimulus]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0000724 [double-strand break repair via homologous recombination] GO:0001922 [B-1 B cell homeostasis] GO:0001934 [positive regulation of protein phosphorylation] GO:0002322 [B cell proliferation involved in immune response] GO:0002333 [transitional one stage B cell differentiation] GO:0003677 [DNA binding] GO:0003785 [actin monomer binding] GO:0004515 [nicotinate-nucleotide adenylyltransferase activity] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006298 [mismatch repair] GO:0006302 [double-strand break repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006909 [phagocytosis] GO:0006914 [autophagy] GO:0006974 [cellular response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0006979 [response to oxidative stress] GO:0007050 [cell cycle arrest] GO:0007067 [mitotic nuclear division] GO:0007155 [cell adhesion] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008022 [protein C-terminus binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010506 [regulation of autophagy] GO:0015629 [actin cytoskeleton] GO:0016301 [kinase activity] GO:0016477 [cell migration] GO:0017124 [SH3 domain binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019904 [protein domain specific binding] GO:0019905 [syntaxin binding] GO:0021587 [cerebellum morphogenesis] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030035 [microspike assembly] GO:0030036 [actin cytoskeleton organization] GO:0030100 [regulation of endocytosis] GO:0030145 [manganese ion binding] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0030514 [negative regulation of BMP signaling pathway] GO:0030516 [regulation of axon extension] GO:0031113 [regulation of microtubule polymerization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031252 [cell leading edge] GO:0031965 [nuclear membrane] GO:0032956 [regulation of actin cytoskeleton organization] GO:0033690 [positive regulation of osteoblast proliferation] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0034599 [cellular response to oxidative stress] GO:0035791 [platelet-derived growth factor receptor-beta signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042100 [B cell proliferation] GO:0042127 [regulation of cell proliferation] GO:0042692 [muscle cell differentiation] GO:0042770 [signal transduction in response to DNA damage] GO:0043065 [positive regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046632 [alpha-beta T cell differentiation] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048536 [spleen development] GO:0048538 [thymus development] GO:0048668 [collateral sprouting] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050798 [activated T cell proliferation] GO:0050853 [B cell receptor signaling pathway] GO:0050885 [neuromuscular process controlling balance] GO:0051015 [actin filament binding] GO:0051019 [mitogen-activated protein kinase binding] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051353 [positive regulation of oxidoreductase activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051726 [regulation of cell cycle] GO:0051882 [mitochondrial depolarization] GO:0060020 [Bergmann glial cell differentiation] GO:0070064 [proline-rich region binding] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071222 [cellular response to lipopolysaccharide] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:0090135 [actin filament branching] GO:1900042 [positive regulation of interleukin-2 secretion] GO:1900275 [negative regulation of phospholipase C activity] GO:1901216 [positive regulation of neuron death] GO:1902715 [positive regulation of interferon-gamma secretion] GO:1903053 [regulation of extracellular matrix organization] GO:1903351 [cellular response to dopamine] GO:1904528 [positive regulation of microtubule binding] GO:1904531 [positive regulation of actin filament binding] GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway] GO:2000145 [regulation of cell motility] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2000352 [negative regulation of endothelial cell apoptotic process] GO:2000772 [regulation of cellular senescence] GO:2000773 [negative regulation of cellular senescence] GO:2001020 [regulation of response to DNA damage stimulus]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)