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ACOT7

GENERAL INFORMATION

Gene name

 ACOT7

Gene description

 Acyl-CoA thioesterase 7

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in selected tissues, including CNS, peripheral nerves, testis and lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA025735 , HPA025762
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA025735
HPA025762

GENE INFORMATION

Gene name

 ACOT7 (HGNC Symbol)

Synonyms

 ACH1, ACT, BACH, CTE-II, hBACH, LACH1, MGC1126

Description

 Acyl-CoA thioesterase 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.31

Chromosome location (bp)

 6264269 - 6394391

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000097021 (version 83.38)

Entrez gene

 11332

UniProt

 O00154 (UniProt - Evidence at protein level)

neXtProt

 NX_O00154

Antibodypedia

 ACOT7 antibodies

PROTEIN BROWSER
ACOT7-001
ACOT7-004
ACOT7-005
ACOT7-006
ACOT7-008
ACOT7-009
ACOT7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOT7-001
ENSP00000367086
ENST00000377855
O00154 [Direct mapping]
Cytosolic acyl coenzyme A thioester hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0009062 [fatty acid catabolic process]
GO:0015937 [coenzyme A biosynthetic process]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036114 [medium-chain fatty-acyl-CoA catabolic process]
GO:0036116 [long-chain fatty-acyl-CoA catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044297 [cell body]
GO:0047617 [acyl-CoA hydrolase activity]
GO:0051792 [medium-chain fatty acid biosynthetic process]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
GO:1900535 [palmitic acid biosynthetic process]
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 380 aa
41.8 kDa 		No 0
ACOT7-004
ENSP00000367076
ENST00000377845
O00154 [Direct mapping]
Cytosolic acyl coenzyme A thioester hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0015937 [coenzyme A biosynthetic process]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036114 [medium-chain fatty-acyl-CoA catabolic process]
GO:0036116 [long-chain fatty-acyl-CoA catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051792 [medium-chain fatty acid biosynthetic process]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
GO:1900535 [palmitic acid biosynthetic process]
Show all
 350 aa
39 kDa 		No 0
ACOT7-005
ENSP00000367073
ENST00000377842
O00154 [Direct mapping]
Cytosolic acyl coenzyme A thioester hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0015937 [coenzyme A biosynthetic process]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036114 [medium-chain fatty-acyl-CoA catabolic process]
GO:0036116 [long-chain fatty-acyl-CoA catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051792 [medium-chain fatty acid biosynthetic process]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
GO:1900535 [palmitic acid biosynthetic process]
Show all
 329 aa
36.6 kDa 		No 0
ACOT7-006
ENSP00000354615
ENST00000361521
O00154 [Direct mapping]
Cytosolic acyl coenzyme A thioester hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0015937 [coenzyme A biosynthetic process]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036114 [medium-chain fatty-acyl-CoA catabolic process]
GO:0036116 [long-chain fatty-acyl-CoA catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051792 [medium-chain fatty acid biosynthetic process]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
GO:1900535 [palmitic acid biosynthetic process]
Show all
 370 aa
40.5 kDa 		No 0
ACOT7-008
ENSP00000465719
ENST00000473466
K7EKP8 [Direct mapping]
Cytosolic acyl coenzyme A thioester hydrolase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 280 aa
30.8 kDa 		No 0
ACOT7-009
ENSP00000476610
ENST00000608083
O00154 [Direct mapping]
Cytosolic acyl coenzyme A thioester hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0015937 [coenzyme A biosynthetic process]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036114 [medium-chain fatty-acyl-CoA catabolic process]
GO:0036116 [long-chain fatty-acyl-CoA catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051792 [medium-chain fatty acid biosynthetic process]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
GO:1900535 [palmitic acid biosynthetic process]
Show all
 338 aa
37.4 kDa 		No 0
ACOT7-201
ENSP00000439218
ENST00000545482
O00154 [Direct mapping]
Cytosolic acyl coenzyme A thioester hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0015937 [coenzyme A biosynthetic process]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036042 [long-chain fatty acyl-CoA binding]
GO:0036114 [medium-chain fatty-acyl-CoA catabolic process]
GO:0036116 [long-chain fatty-acyl-CoA catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051792 [medium-chain fatty acid biosynthetic process]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
GO:1900535 [palmitic acid biosynthetic process]
Show all
 370 aa
40.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.