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Pancreatic cancers showed moderate to strong cytoplasmic and/or membranous positivity. Several cases of colorectal, breast, prostate, endometrial, gastric, liver and ovarian cancers displayed weak to moderate positivity. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
TSPAN15 (HGNC Symbol)
Synonyms
NET-7, TM4SF15
Description
Tetraspanin 15 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]