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Colorectal, pancreatic and gastric cancers as well as several ovarian cancers showed moderate to strong cytoplasmic positivity. Moderate staining was observed in hepatocellular carcinomas and a few cases of renal and urothelial cancers. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
MYO9B (HGNC Symbol)
Synonyms
CELIAC4
Description
Myosin IXB (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]