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KCNK6

GENERAL INFORMATION

Gene name

 KCNK6

Gene description

 Potassium channel, two pore domain subfamily K, member 6

Protein class

 Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEL, HMC-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA040184 , CAB022637
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA040184
CAB022637

GENE INFORMATION

Gene name

 KCNK6 (HGNC Symbol)

Synonyms

 K2p6.1, TWIK-2

Description

 Potassium channel, two pore domain subfamily K, member 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 38319844 - 38332076

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099337 (version 83.38)

Entrez gene

 9424

UniProt

 Q9Y257 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y257

Antibodypedia

 KCNK6 antibodies

PROTEIN BROWSER
KCNK6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNK6-001
ENSP00000263372
ENST00000263372
Q9Y257 [Direct mapping]
Potassium channel subfamily K member 6
B2RDS2 [Target identity:100%; Query identity:100%]
K2P6.1 potassium channel; Potassium channel, subfamily K, member 6; cDNA, FLJ96744, Homo sapiens potassium channel, subfamily K, member 6 (KCNK6),mRNA
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Two-P Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
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GO:0003073 [regulation of systemic arterial blood pressure]
GO:0003085 [negative regulation of systemic arterial blood pressure]
GO:0005242 [inward rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0022841 [potassium ion leak channel activity]
GO:0030322 [stabilization of membrane potential]
GO:0034765 [regulation of ion transmembrane transport]
GO:0060075 [regulation of resting membrane potential]
GO:0071805 [potassium ion transmembrane transport]
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 313 aa
33.7 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.