Expression of BCL7C in cancer - Summary - The Human Protein Atlas

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BCL7C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BCL7C
Gene description	B-cell CLL/lymphoma 7C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA018676
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018676

GENE INFORMATION
Gene name	BCL7C
Synonyms
Description	B-cell CLL/lymphoma 7C (HGNC Symbol)
Entrez gene summary	This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	30833626 - 30894960
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099385 (version 83.38)
Entrez gene	9274
UniProt	Q8WUZ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WUZ0
Antibodypedia	BCL7C antibodies

PROTEIN BROWSER

BCL7C-001	BCL7C-002	BCL7C-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL7C-001 ENSP00000215115 ENST00000215115	Q8WUZ0 [Direct mapping] B-cell CLL/lymphoma 7 protein family member C Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] Show all	217 aa 23.5 kDa	No	0
BCL7C-002 ENSP00000369674 ENST00000380317	Q8WUZ0 [Direct mapping] B-cell CLL/lymphoma 7 protein family member C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] Show all	242 aa 26.4 kDa	No	0
BCL7C-004 ENSP00000459007 ENST00000572628	I3L1Q2 [Direct mapping] B-cell CLL/lymphoma 7 protein family member C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		293 aa 32.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.