Tissue expression of EFNA2 - Summary - The Human Protein Atlas

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EFNA2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	EFNA2
Gene description	Ephrin-A2
Protein class	Cancer-related genes Predicted secreted proteins RAS pathway related proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (colon, duodenum, small intestine)
GTEx:	Group enriched (colon, liver, small intestine)
FANTOM5:	Tissue enhanced (small intestine)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. CAB005178
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, duodenum, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, liver, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION
Gene name	EFNA2 (HGNC Symbol)
Synonyms	ELF-1, EPLG6, LERK6
Description	Ephrin-A2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	1286154 - 1300237
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099617 (version 83.38)
Entrez gene	1943
UniProt	O43921 (UniProt - Evidence at protein level)
neXtProt	NX_O43921
Antibodypedia	EFNA2 antibodies

PROTEIN BROWSER

EFNA2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EFNA2-001 ENSP00000215368 ENST00000215368	O43921 [Direct mapping] Ephrin-A2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0021772 [olfactory bulb development] GO:0030316 [osteoclast differentiation] GO:0031225 [anchored component of membrane] GO:0031594 [neuromuscular junction] GO:0043204 [perikaryon] GO:0046849 [bone remodeling] GO:0046875 [ephrin receptor binding] GO:0048013 [ephrin receptor signaling pathway] Show all	213 aa 23.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.