Expression of IGFALS in cancer - Summary

GENERAL INFORMATION
Gene name	IGFALS
Gene description	Insulin-like growth factor binding protein, acid labile subunit
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (liver cancer)
HPA (cell line):	Cell line enhanced (Hep G2, U-266/70)
HPA (normal tissue):	Group enriched (liver, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in liver, gallbladder and stomach. Extracellular deposits in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA040692 , HPA040948
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA040692	HPA040948

GENE INFORMATION
Gene name	IGFALS (HGNC Symbol)
Synonyms	ALS
Description	Insulin-like growth factor binding protein, acid labile subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1790413 - 1794971
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099769 (version 83.38)
Entrez gene	3483
UniProt	P35858 (UniProt - Evidence at protein level)
neXtProt	NX_P35858
Antibodypedia	IGFALS antibodies

PROTEIN BROWSER

IGFALS-001	IGFALS-002	IGFALS-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGFALS-001 ENSP00000215539 ENST00000215539	P35858 [Direct mapping] Insulin-like growth factor-binding protein complex acid labile subunit Show all	MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0042567 [insulin-like growth factor ternary complex] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	605 aa 66 kDa	Yes	0
IGFALS-002 ENSP00000416683 ENST00000415638	P35858 [Direct mapping] Insulin-like growth factor-binding protein complex acid labile subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0042567 [insulin-like growth factor ternary complex] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	643 aa 70.2 kDa	No	1
IGFALS-004 ENSP00000456923 ENST00000568221	H3BSX8 [Direct mapping] Insulin-like growth factor-binding protein complex acid labile subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 14.4 kDa	No	0