Cell atlas - HNRNPM - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HNRNPM
Gene description	Heterogeneous nuclear ribonucleoprotein M
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB016113 , HPA024344
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
CAB016113	A-431	Nucleoplasm
CAB016113	U-2 OS	Nucleoplasm
CAB016113	U-251 MG	Nucleoplasm
HPA024344	A-431	Nucleoplasm
HPA024344	U-2 OS	Nucleoplasm
HPA024344	U-251 MG	Nucleoplasm

siRNA VALIDATION

Antibody

HPA024344

siRNA validation

Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

26%

22%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA024344	siRNA 1	U-2 OS
HPA024344	siRNA 2	U-2 OS
HPA024344	scrambled	U-2 OS

GENE INFORMATION
Gene name	HNRNPM (HGNC Symbol)
Synonyms	CEAR, HNRNPM4, HNRPM, HNRPM4, HTGR1, NAGR1
Description	Heterogeneous nuclear ribonucleoprotein M (HGNC Symbol)
Entrez gene summary	This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	8444767 - 8489114
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099783 (version 83.38)
Entrez gene	4670
UniProt	P52272 (UniProt - Evidence at protein level)
neXtProt	NX_P52272
Antibodypedia	HNRNPM antibodies

PROTEIN BROWSER

HNRNPM-001	HNRNPM-002	HNRNPM-003	HNRNPM-007	HNRNPM-008	HNRNPM-009	HNRNPM-010	HNRNPM-012	HNRNPM-015	HNRNPM-017	HNRNPM-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HNRNPM-001 ENSP00000325732 ENST00000348943	P52272 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000380 [alternative mRNA splicing, via spliceosome] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0005730 [nucleolus] GO:0005887 [integral component of plasma membrane] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016363 [nuclear matrix] GO:0019904 [protein domain specific binding] GO:0031012 [extracellular matrix] GO:0042382 [paraspeckles] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] GO:0071013 [catalytic step 2 spliceosome] Show all	691 aa 73.6 kDa	No	0
HNRNPM-002 ENSP00000325376 ENST00000325495	P52272 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000380 [alternative mRNA splicing, via spliceosome] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0005730 [nucleolus] GO:0005887 [integral component of plasma membrane] GO:0008380 [RNA splicing] GO:0009986 [cell surface] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016363 [nuclear matrix] GO:0019904 [protein domain specific binding] GO:0031012 [extracellular matrix] GO:0042382 [paraspeckles] GO:0044822 [poly(A) RNA binding] GO:0048306 [calcium-dependent protein binding] GO:0070062 [extracellular exosome] GO:0071013 [catalytic step 2 spliceosome] GO:0071222 [cellular response to lipopolysaccharide] GO:1900182 [positive regulation of protein localization to nucleus] GO:1904591 [positive regulation of protein import] GO:1990405 [protein antigen binding] GO:1990831 [cellular response to carcinoembryonic antigen] Show all	730 aa 77.5 kDa	No	0
HNRNPM-003 ENSP00000470932 ENST00000600092	M0R019 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	353 aa 37.7 kDa	No	0
HNRNPM-007 ENSP00000470635 ENST00000597270	M0QZM1 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	383 aa 39.9 kDa	No	0
HNRNPM-008 ENSP00000469906 ENST00000598367	M0QYL3 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003723 [RNA binding] Show all	99 aa 10 kDa	No	0
HNRNPM-009 ENSP00000471339 ENST00000601645	M0R0N3 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	276 aa 30.1 kDa	No	0
HNRNPM-010 ENSP00000470017 ENST00000596984	M0QYQ7 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	219 aa 24.1 kDa	No	0
HNRNPM-012 ENSP00000472599 ENST00000596295	M0R2I7 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003723 [RNA binding] Show all	214 aa 22.6 kDa	No	0
HNRNPM-015 ENSP00000469681 ENST00000598999	M0QY96 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	116 aa 12.3 kDa	No	0
HNRNPM-017 ENSP00000472789 ENST00000594907	M0R2T0 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	357 aa 38.2 kDa	No	0
HNRNPM-201 ENSP00000483715 ENST00000620401	A0A087X0X3 [Direct mapping] Heterogeneous nuclear ribonucleoprotein M Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	730 aa 77.6 kDa	No	0