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TIMM13

GENERAL INFORMATION

Gene name

 TIMM13

Gene description

 Translocase of inner mitochondrial membrane 13 homolog (yeast)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA048985
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048985

GENE INFORMATION

Gene name

 TIMM13 (HGNC Symbol)

Synonyms

 Tim13, TIMM13B

Description

 Translocase of inner mitochondrial membrane 13 homolog (yeast) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that function as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family play a role in collecting substrate proteins from the translocase of the outer mitochondrial membrane (TOM) complex and delivering them to either the sorting and assembly machinery in the outer mitochondrial membrane (SAM) complex or the TIMM22 complex in the inner mitochondrial membrane. The encoded protein and the translocase of mitochondrial inner membrane 8a protein form a 70 kDa complex in the intermembrane space. [provided by RefSeq, Jul 2013]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 2425624 - 2427894

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099800 (version 83.38)

Entrez gene

 26517

UniProt

 Q9Y5L4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5L4

Antibodypedia

 TIMM13 antibodies

PROTEIN BROWSER
TIMM13-001
TIMM13-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TIMM13-001
ENSP00000215570
ENST00000215570
Q9Y5L4 [Direct mapping]
Mitochondrial import inner membrane translocase subunit Tim13
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006626 [protein targeting to mitochondrion]
GO:0007605 [sensory perception of sound]
GO:0008270 [zinc ion binding]
GO:0042719 [mitochondrial intermembrane space protein transporter complex]
GO:0044267 [cellular protein metabolic process]
GO:0072321 [chaperone-mediated protein transport]
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 95 aa
10.5 kDa 		No 0
TIMM13-002
ENSP00000464881
ENST00000591871
K7EIT2 [Direct mapping]
Mitochondrial import inner membrane translocase subunit Tim13; Translocase of inner mitochondrial membrane 13 homolog (Yeast), isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0015031 [protein transport]
GO:0046872 [metal ion binding]
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 80 aa
8.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.