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CDC34

GENERAL INFORMATION

Gene name

 CDC34

Gene description

 Cell division cycle 34

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in most tissues at variable levels.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA002382 , CAB005109 , CAB047311
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CDC34 (HGNC Symbol)

Synonyms

 E2-CDC34, UBC3, UBE2R1

Description

 Cell division cycle 34 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 531712 - 542092

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099804 (version 83.38)

Entrez gene

 997

UniProt

 P49427 (UniProt - Evidence at protein level)

neXtProt

 NX_P49427

Antibodypedia

 CDC34 antibodies

PROTEIN BROWSER
CDC34-001
CDC34-003
CDC34-004
CDC34-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC34-001
ENSP00000215574
ENST00000215574
P49427 [Direct mapping]
Ubiquitin-conjugating enzyme E2 R1
A0A024R1Z1 [Target identity:100%; Query identity:100%]
Cell division cycle 34, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006270 [DNA replication initiation]
GO:0006464 [cellular protein modification process]
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035458 [cellular response to interferon-beta]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070848 [response to growth factor]
GO:0070936 [protein K48-linked ubiquitination]
GO:0090261 [positive regulation of inclusion body assembly]
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 236 aa
26.7 kDa 		No 0
CDC34-003
ENSP00000476107
ENST00000607527
U3KQP9 [Direct mapping]
Ubiquitin-conjugating enzyme E2 R1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
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 107 aa
12.2 kDa 		No 0
CDC34-004
ENSP00000475610
ENST00000606065
U3KQ77 [Direct mapping]
Ubiquitin-conjugating enzyme E2 R1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
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 119 aa
13.8 kDa 		No 0
CDC34-005
ENSP00000475282
ENST00000586283
U3KPV8 [Direct mapping]
Ubiquitin-conjugating enzyme E2 R1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 146 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.