Cell atlas - MTAP - The Human Protein Atlas

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MTAP

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	MTAP
Gene description	Methylthioadenosine phosphorylase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA046915
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046915	A-431	No staining
	HPA046915	U-2 OS	No staining
	HPA046915	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MTAP (HGNC Symbol)
Synonyms	c86fus, MSAP
Description	Methylthioadenosine phosphorylase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p21.3
Chromosome location (bp)	21802543 - 21937651
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099810 (version 83.38)
Entrez gene	4507
UniProt	Q13126 (UniProt - Evidence at protein level)
neXtProt	NX_Q13126
Antibodypedia	MTAP antibodies

PROTEIN BROWSER

MTAP-001	MTAP-003	MTAP-008	MTAP-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTAP-001 ENSP00000369519 ENST00000380172	Q13126 [Direct mapping] S-methyl-5'-thioadenosine phosphorylase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0003824 [catalytic activity] GO:0004645 [phosphorylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006166 [purine ribonucleoside salvage] GO:0006595 [polyamine metabolic process] GO:0009116 [nucleoside metabolic process] GO:0016763 [transferase activity, transferring pentosyl groups] GO:0017061 [S-methyl-5-thioadenosine phosphorylase activity] GO:0019509 [L-methionine biosynthetic process from methylthioadenosine] GO:0034641 [cellular nitrogen compound metabolic process] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	283 aa 31.2 kDa	No	0
MTAP-003 ENSP00000461932 ENST00000460874	B4DUC8 [Direct mapping] S-methyl-5'-thioadenosine phosphorylase; cDNA FLJ59758, highly similar to S-methyl-5-thioadenosine phosphorylase (EC 2.4.2.28) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005737 [cytoplasm] GO:0009116 [nucleoside metabolic process] GO:0016763 [transferase activity, transferring pentosyl groups] GO:0017061 [S-methyl-5-thioadenosine phosphorylase activity] GO:0043101 [purine-containing compound salvage] Show all	300 aa 33.2 kDa	No	0
MTAP-008 ENSP00000463424 ENST00000580900	Q13126 [Direct mapping] S-methyl-5'-thioadenosine phosphorylase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0003824 [catalytic activity] GO:0004645 [phosphorylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006166 [purine ribonucleoside salvage] GO:0006595 [polyamine metabolic process] GO:0009116 [nucleoside metabolic process] GO:0016763 [transferase activity, transferring pentosyl groups] GO:0017061 [S-methyl-5-thioadenosine phosphorylase activity] GO:0019509 [L-methionine biosynthetic process from methylthioadenosine] GO:0034641 [cellular nitrogen compound metabolic process] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	334 aa 36.9 kDa	No	0
MTAP-009 ENSP00000462082 ENST00000577563	J3KRN1 [Direct mapping] S-methyl-5'-thioadenosine phosphorylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009116 [nucleoside metabolic process] GO:0017061 [S-methyl-5-thioadenosine phosphorylase activity] GO:0043101 [purine-containing compound salvage] Show all	112 aa 12.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.