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POLR2E

GENERAL INFORMATION

Gene name

 POLR2E

Gene description

 Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA068992
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA068992

GENE INFORMATION

Gene name

 POLR2E (HGNC Symbol)

Synonyms

 hRPB25, hsRPB5, RPABC1, RPB5, XAP4

Description

 Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 1086579 - 1095380

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099817 (version 83.38)

Entrez gene

 5434

UniProt

 P19388 (UniProt - Evidence at protein level)

neXtProt

 NX_P19388

Antibodypedia

 POLR2E antibodies

PROTEIN BROWSER
POLR2E-001
POLR2E-009
POLR2E-010
POLR2E-013
POLR2E-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR2E-001
ENSP00000478303
ENST00000615234
P19388 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC1
E5KT65 [Target identity:100%; Query identity:100%]
DNA-directed RNA polymerase subunit RPABC1
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032481 [positive regulation of type I interferon production]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
Show all
 210 aa
24.6 kDa 		No 0
POLR2E-009
ENSP00000479813
ENST00000619917
A0A087WVZ9 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC1
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 184 aa
21.5 kDa 		No 0
POLR2E-010
ENSP00000464739
ENST00000586746
P19388 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC1
E5KT65 [Target identity:100%; Query identity:100%]
DNA-directed RNA polymerase subunit RPABC1
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032481 [positive regulation of type I interferon production]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
Show all
 210 aa
24.6 kDa 		No 0
POLR2E-013
ENSP00000485021
ENST00000612655
P19388 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC1
E5KT65 [Target identity:100%; Query identity:100%]
DNA-directed RNA polymerase subunit RPABC1
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032481 [positive regulation of type I interferon production]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0050434 [positive regulation of viral transcription]
Show all
 210 aa
24.6 kDa 		No 0
POLR2E-014
ENSP00000480562
ENST00000585838
A0A087WWX0 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
Show all
 134 aa
15.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.