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PALM

GENERAL INFORMATION

Gene name

 PALM

Gene description

 Paralemmin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AN3-CA, REH, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High expression of renal tubules and neuropil.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA041713 , HPA049578
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041713
HPA049578

GENE INFORMATION

Gene name

 PALM (HGNC Symbol)

Synonyms

 KIAA0270

Description

 Paralemmin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 708939 - 748329

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099864 (version 83.38)

Entrez gene

 5064

UniProt

 O75781 (UniProt - Evidence at protein level)

neXtProt

 NX_O75781

Antibodypedia

 PALM antibodies

PROTEIN BROWSER
PALM-001
PALM-002
PALM-004
PALM-006
PALM-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PALM-001
ENSP00000341911
ENST00000338448
O75781 [Direct mapping]
Paralemmin-1
A0A024R1Y6 [Target identity:100%; Query identity:100%]
Paralemmin, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0008104 [protein localization]
GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016323 [basolateral plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0031527 [filopodium membrane]
GO:0031750 [D3 dopamine receptor binding]
GO:0032590 [dendrite membrane]
GO:0032591 [dendritic spine membrane]
GO:0043197 [dendritic spine]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044309 [neuron spine]
GO:0051491 [positive regulation of filopodium assembly]
GO:0060074 [synapse maturation]
GO:0060160 [negative regulation of dopamine receptor signaling pathway]
GO:0060999 [positive regulation of dendritic spine development]
GO:0071257 [cellular response to electrical stimulus]
GO:0072661 [protein targeting to plasma membrane]
GO:0097481 [neuronal postsynaptic density]
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 387 aa
42.1 kDa 		No 0
PALM-002
ENSP00000264560
ENST00000264560
O75781 [Direct mapping]
Paralemmin-1
A0A024R207 [Target identity:100%; Query identity:100%]
Paralemmin, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016323 [basolateral plasma membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0030424 [axon]
GO:0031527 [filopodium membrane]
GO:0043197 [dendritic spine]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051491 [positive regulation of filopodium assembly]
GO:0060160 [negative regulation of dopamine receptor signaling pathway]
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 343 aa
37.2 kDa 		No 0
PALM-004
ENSP00000477952
ENST00000592155
A0A087WTK8 [Direct mapping]
Paralemmin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
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 242 aa
25.7 kDa 		No 0
PALM-006
ENSP00000480594
ENST00000590161
A0A087WWY4 [Direct mapping]
Paralemmin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
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 198 aa
20.8 kDa 		No 0
PALM-008
ENSP00000484090
ENST00000586055
A0A087X1D6 [Direct mapping]
Paralemmin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 13 aa
1.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.