Cell atlas - MADCAM1 - The Human Protein Atlas

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MADCAM1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	MADCAM1
Gene description	Mucosal vascular addressin cell adhesion molecule 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	MADCAM1 (HGNC Symbol)
Synonyms	MACAM1
Description	Mucosal vascular addressin cell adhesion molecule 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	489176 - 505342
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099866 (version 83.38)
Entrez gene	8174
UniProt	Q13477 (UniProt - Evidence at protein level)
neXtProt	NX_Q13477
Antibodypedia	MADCAM1 antibodies

PROTEIN BROWSER

MADCAM1-001	MADCAM1-002	MADCAM1-003	MADCAM1-004	MADCAM1-201	MADCAM1-202	MADCAM1-203	MADCAM1-204	MADCAM1-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MADCAM1-001 ENSP00000304247 ENST00000346144	Q13477 [Direct mapping] Mucosal addressin cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002687 [positive regulation of leukocyte migration] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007229 [integrin-mediated signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030198 [extracellular matrix organization] GO:0034113 [heterotypic cell-cell adhesion] GO:0043113 [receptor clustering] GO:0050776 [regulation of immune response] GO:0050901 [leukocyte tethering or rolling] GO:0098640 [integrin binding involved in cell-matrix adhesion] Show all	295 aa 31.1 kDa	Yes	1
MADCAM1-002 ENSP00000215637 ENST00000215637	Q13477 [Direct mapping] Mucosal addressin cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002687 [positive regulation of leukocyte migration] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007229 [integrin-mediated signaling pathway] GO:0007568 [aging] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030198 [extracellular matrix organization] GO:0030216 [keratinocyte differentiation] GO:0034113 [heterotypic cell-cell adhesion] GO:0043113 [receptor clustering] GO:0050776 [regulation of immune response] GO:0050900 [leukocyte migration] GO:0050901 [leukocyte tethering or rolling] GO:0098640 [integrin binding involved in cell-matrix adhesion] Show all	382 aa 40.2 kDa	Yes	1
MADCAM1-003 ENSP00000372130 ENST00000382683	Q13477 [Direct mapping] Mucosal addressin cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002687 [positive regulation of leukocyte migration] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007229 [integrin-mediated signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030198 [extracellular matrix organization] GO:0034113 [heterotypic cell-cell adhesion] GO:0043113 [receptor clustering] GO:0050776 [regulation of immune response] GO:0050901 [leukocyte tethering or rolling] GO:0098640 [integrin binding involved in cell-matrix adhesion] Show all	200 aa 21.2 kDa	Yes	1
MADCAM1-004 ENSP00000475575 ENST00000587541	U3KQ59 [Direct mapping] Mucosal addressin cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	163 aa 17 kDa	No	1
MADCAM1-201 ENSP00000480908 ENST00000613880	A0A087WXC9 [Direct mapping] Mucosal addressin cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	406 aa 42.4 kDa	Yes	1
MADCAM1-202 ENSP00000484317 ENST00000617201	A0A087X1M5 [Direct mapping] Mucosal addressin cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	400 aa 42.2 kDa	Yes	1
MADCAM1-203 ENSP00000484153 ENST00000619333	A0A087X1F1 [Direct mapping] Mucosal addressin cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	398 aa 41.8 kDa	Yes	1
MADCAM1-204 ENSP00000483663 ENST00000621286	A0A087X0U8 [Direct mapping] Mucosal addressin cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	400 aa 42.2 kDa	Yes	1
MADCAM1-205 ENSP00000480104 ENST00000622462	A0A087WWC0 [Direct mapping] Mucosal addressin cell adhesion molecule 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	390 aa 40.9 kDa	Yes	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.