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MKNK2

GENERAL INFORMATION

Gene name

 MKNK2

Gene description

 MAP kinase interacting serine/threonine kinase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA021875 , CAB037253
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and stomach cancer (favourable).
Endometrial cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA021875
CAB037253

GENE INFORMATION

Gene name

 MKNK2 (HGNC Symbol)

Synonyms

 GPRK7, MNK2

Description

 MAP kinase interacting serine/threonine kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 2037465 - 2051244

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099875 (version 83.38)

Entrez gene

 2872

UniProt

 Q9HBH9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBH9

Antibodypedia

 MKNK2 antibodies

PROTEIN BROWSER
MKNK2-001
MKNK2-004
MKNK2-005
MKNK2-006
MKNK2-009
MKNK2-010
MKNK2-012
MKNK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MKNK2-001
ENSP00000309485
ENST00000309340
Q9HBH9 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0016605 [PML body]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030097 [hemopoiesis]
GO:0035556 [intracellular signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0071243 [cellular response to arsenic-containing substance]
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 414 aa
46.7 kDa 		No 0
MKNK2-004
ENSP00000467811
ENST00000591601
Q9HBH9 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0016605 [PML body]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030097 [hemopoiesis]
GO:0035556 [intracellular signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0071243 [cellular response to arsenic-containing substance]
Show all
 465 aa
51.9 kDa 		No 0
MKNK2-005
ENSP00000465645
ENST00000591142
Q9NV89 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 2; MKNK2 protein; cDNA FLJ10868 fis, clone NT2RP4001644, weakly similar to MYOSIN LIGHT CHAIN KINASE (EC 2.7.1.117)
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0046777 [protein autophosphorylation]
Show all
 158 aa
17.7 kDa 		No 0
MKNK2-006
ENSP00000466147
ENST00000589509
K7ELN0 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0046777 [protein autophosphorylation]
Show all
 76 aa
8.2 kDa 		No 0
MKNK2-009
ENSP00000464828
ENST00000591588
K7EIN7 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 2
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0046777 [protein autophosphorylation]
Show all
 129 aa
14.4 kDa 		No 0
MKNK2-010
ENSP00000465079
ENST00000588014
K7EJ98 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 2
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0046777 [protein autophosphorylation]
Show all
 176 aa
19.4 kDa 		No 0
MKNK2-012
ENSP00000466064
ENST00000589534
K7ELG3 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0046777 [protein autophosphorylation]
Show all
 74 aa
8 kDa 		No 0
MKNK2-201
ENSP00000250896
ENST00000250896
Q9HBH9 [Direct mapping]
MAP kinase-interacting serine/threonine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009931 [calcium-dependent protein serine/threonine kinase activity]
GO:0016605 [PML body]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030097 [hemopoiesis]
GO:0035556 [intracellular signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0071243 [cellular response to arsenic-containing substance]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 465 aa
51.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.