Expression of SERPIND1 in cancer - Summary - The Human Protein Atlas

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SERPIND1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SERPIND1
Gene description	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Protein class	Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in plasma.

ANTIBODY IHC RELIABILITY
Data reliability description	No internal RNA expression data available for correlation. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA055767 , CAB008639
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055767	CAB008639

GENE INFORMATION
Gene name	SERPIND1 (HGNC Symbol)
Synonyms	D22S673, HC-II, HC2, HCF2, HLS2
Description	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (HGNC Symbol)
Entrez gene summary	This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	20773879 - 20787720
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099937 (version 83.38)
Entrez gene	3053
UniProt	P05546 (UniProt - Evidence at protein level)
neXtProt	NX_P05546
Antibodypedia	SERPIND1 antibodies

PROTEIN BROWSER

SERPIND1-001	SERPIND1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPIND1-001 ENSP00000215727 ENST00000215727	P05546 [Direct mapping] Heparin cofactor 2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0008218 [bioluminescence] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	499 aa 57.1 kDa	Yes	0
SERPIND1-002 ENSP00000384050 ENST00000406799	P05546 [Direct mapping] Heparin cofactor 2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0008218 [bioluminescence] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	499 aa 57.1 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.