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SNAP29

GENERAL INFORMATION

Gene name

 SNAP29

Gene description

 Synaptosomal-associated protein, 29kDa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA031823 , CAB037092
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA031823
CAB037092

GENE INFORMATION

Gene name

 SNAP29 (HGNC Symbol)

Synonyms

 CEDNIK, SNAP-29

Description

 Synaptosomal-associated protein, 29kDa (HGNC Symbol)

Entrez gene summary

 This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 20858983 - 20891218

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099940 (version 83.38)

Entrez gene

 9342

UniProt

 O95721 (UniProt - Evidence at protein level)

neXtProt

 NX_O95721

Antibodypedia

 SNAP29 antibodies

PROTEIN BROWSER
SNAP29-001
SNAP29-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNAP29-001
ENSP00000215730
ENST00000215730
O95721 [Direct mapping]
Synaptosomal-associated protein 29
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0000421 [autophagosome membrane]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0006903 [vesicle targeting]
GO:0015031 [protein transport]
GO:0016082 [synaptic vesicle priming]
GO:0019905 [syntaxin binding]
GO:0020018 [ciliary pocket membrane]
GO:0031201 [SNARE complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0042384 [cilium assembly]
GO:0061025 [membrane fusion]
GO:0097352 [autophagosome maturation]
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 258 aa
29 kDa 		No 0
SNAP29-003
ENSP00000411095
ENST00000439214
C9JAF7 [Direct mapping]
Synaptosomal-associated protein 29
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005623 [cell]
GO:0016082 [synaptic vesicle priming]
GO:0019905 [syntaxin binding]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
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 160 aa
18 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.