Expression of LZTR1 in cancer - Summary - The Human Protein Atlas

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LZTR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LZTR1
Gene description	Leucine-zipper-like transcription regulator 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Approved based on 2 antibodies. HPA068772 , HPA071248
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA068772	HPA071248

GENE INFORMATION
Gene name	LZTR1 (HGNC Symbol)
Synonyms	BTBD29, LZTR-1
Description	Leucine-zipper-like transcription regulator 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	20979462 - 20999038
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099949 (version 83.38)
Entrez gene	8216
UniProt	Q8N653 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N653
Antibodypedia	LZTR1 antibodies

PROTEIN BROWSER

LZTR1-001	LZTR1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LZTR1-001 ENSP00000215739 ENST00000215739	Q8N653 [Direct mapping] Leucine-zipper-like transcriptional regulator 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0009653 [anatomical structure morphogenesis] Show all	840 aa 94.7 kDa	No	0
LZTR1-004 ENSP00000397252 ENST00000415817	H7C0X1 [Direct mapping] Leucine-zipper-like transcriptional regulator 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	158 aa 17.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.