Cell atlas - MMP11 - The Human Protein Atlas

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MMP11

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	MMP11
Gene description	Matrix metallopeptidase 11
Protein class	Cancer-related genes Enzymes FDA approved drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (AN3-CA, REH)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, REH) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	MMP11 (HGNC Symbol)
Synonyms	STMY3
Description	Matrix metallopeptidase 11 (HGNC Symbol)
Entrez gene summary	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	23768226 - 23784316
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099953 (version 83.38)
Entrez gene	4320
UniProt	P24347 (UniProt - Evidence at protein level)
neXtProt	NX_P24347
Antibodypedia	MMP11 antibodies

PROTEIN BROWSER

MMP11-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MMP11-001 ENSP00000215743 ENST00000215743	P24347 [Direct mapping] Stromelysin-3 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Show all	GO:0004222 [metalloendopeptidase activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005796 [Golgi lumen] GO:0006508 [proteolysis] GO:0007275 [multicellular organismal development] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0045599 [negative regulation of fat cell differentiation] GO:0071711 [basement membrane organization] Show all	488 aa 54.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.