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P2RX6

GENERAL INFORMATION

Gene name

 P2RX6

Gene description

 Purinergic receptor P2X, ligand gated ion channel, 6

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels in several tissues, highly abundant in heart and skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA028776 , HPA028777
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION

Gene name

 P2RX6 (HGNC Symbol)

Synonyms

 MGC129625, P2RXL1, P2X6, P2XM

Description

 Purinergic receptor P2X, ligand gated ion channel, 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 21009808 - 21028830

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099957 (version 83.38)

Entrez gene

 9127

UniProt

 O15547 (UniProt - Evidence at protein level)

neXtProt

 NX_O15547

Antibodypedia

 P2RX6 antibodies

PROTEIN BROWSER
P2RX6-001
P2RX6-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
P2RX6-001
ENSP00000416193
ENST00000413302
O15547 [Direct mapping]
P2X purinoceptor 6
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0014069 [postsynaptic density]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0098655 [cation transmembrane transport]
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 441 aa
48.8 kDa 		No 2
P2RX6-003
ENSP00000385309
ENST00000401443
O15547 [Direct mapping]
P2X purinoceptor 6
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0006936 [muscle contraction]
GO:0007165 [signal transduction]
GO:0015267 [channel activity]
GO:0030054 [cell junction]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0051260 [protein homooligomerization]
GO:0098655 [cation transmembrane transport]
Show all
 415 aa
45.8 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.