Expression of DERL3 in cancer - Summary - The Human Protein Atlas

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DERL3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DERL3
Gene description	Derlin 3
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (Karpas-707, RPMI-8226, U-266/70, U-698)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several cell types at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB037234
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB037234

GENE INFORMATION
Gene name	DERL3 (HGNC Symbol)
Synonyms	C22orf14, derlin-3, FLJ43842, IZP6, MGC71803
Description	Derlin 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	23834503 - 23839128
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099958 (version 83.38)
Entrez gene	91319
UniProt	Q96Q80 (UniProt - Evidence at protein level)
neXtProt	NX_Q96Q80
Antibodypedia	DERL3 antibodies

PROTEIN BROWSER

DERL3-001	DERL3-002	DERL3-003	DERL3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DERL3-001 ENSP00000384744 ENST00000406855	Q96Q80 [Direct mapping] Derlin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Show all	GO:0005515 [protein binding] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	239 aa 26.6 kDa	No	4
DERL3-002 ENSP00000315303 ENST00000318109	Q96Q80 [Direct mapping] Derlin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Show all	GO:0005515 [protein binding] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	235 aa 26.7 kDa	No	5
DERL3-003 ENSP00000419399 ENST00000476077	Q96Q80 [Direct mapping] Derlin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Show all	GO:0005515 [protein binding] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	205 aa 23.4 kDa	No	5
DERL3-005 ENSP00000384473 ENST00000404056	E7EVA4 [Direct mapping] Derlin-3 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		178 aa 19.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.