Expression of CABIN1 in cancer - Summary - The Human Protein Atlas

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CABIN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CABIN1
Gene description	Calcineurin binding protein 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043296
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and renal cancer (favourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043296

GENE INFORMATION
Gene name	CABIN1 (HGNC Symbol)
Synonyms	KIAA0330, PPP3IN
Description	Calcineurin binding protein 1 (HGNC Symbol)
Entrez gene summary	Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	24011192 - 24178628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099991 (version 83.38)
Entrez gene	23523
UniProt	Q9Y6J0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6J0
Antibodypedia	CABIN1 antibodies

PROTEIN BROWSER

CABIN1-001	CABIN1-002	CABIN1-003	CABIN1-004	CABIN1-013	CABIN1-014	CABIN1-201	CABIN1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CABIN1-001 ENSP00000381364 ENST00000398319	Q9Y6J0 [Direct mapping] Calcineurin-binding protein cabin-1 A0A024R1E5 [Target identity:100%; Query identity:100%] Calcineurin binding protein 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006336 [DNA replication-independent nucleosome assembly] GO:0007166 [cell surface receptor signaling pathway] GO:0014823 [response to activity] GO:0016235 [aggresome] GO:0016568 [chromatin modification] GO:0019904 [protein domain specific binding] GO:0030346 [protein phosphatase 2B binding] GO:0031491 [nucleosome binding] GO:0043086 [negative regulation of catalytic activity] GO:0060548 [negative regulation of cell death] Show all	2220 aa 246.4 kDa	No	0
CABIN1-002 ENSP00000384694 ENST00000405822	Q9Y6J0 [Direct mapping] Calcineurin-binding protein cabin-1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006336 [DNA replication-independent nucleosome assembly] GO:0007166 [cell surface receptor signaling pathway] GO:0016235 [aggresome] GO:0016568 [chromatin modification] GO:0031491 [nucleosome binding] GO:0043086 [negative regulation of catalytic activity] Show all	2141 aa 237.6 kDa	No	0
CABIN1-003 ENSP00000412389 ENST00000445422	C9J068 [Direct mapping] Calcineurin-binding protein cabin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	361 aa 40.5 kDa	No	0
CABIN1-004 ENSP00000336991 ENST00000337989	B5MEB3 [Direct mapping] Calcineurin binding protein 1, isoform CRA_c; Calcineurin-binding protein cabin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016235 [aggresome] Show all	590 aa 63.3 kDa	No	0
CABIN1-013 ENSP00000394209 ENST00000454754	C9JT60 [Direct mapping] Calcineurin-binding protein cabin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	357 aa 40 kDa	No	0
CABIN1-014 ENSP00000263119 ENST00000263119	Q9Y6J0 [Direct mapping] Calcineurin-binding protein cabin-1 A0A024R1E5 [Target identity:100%; Query identity:100%] Calcineurin binding protein 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006336 [DNA replication-independent nucleosome assembly] GO:0007166 [cell surface receptor signaling pathway] GO:0016235 [aggresome] GO:0016568 [chromatin modification] GO:0031491 [nucleosome binding] GO:0043086 [negative regulation of catalytic activity] Show all	2220 aa 246.4 kDa	No	0
CABIN1-201 ENSP00000480560 ENST00000617531	A0A087WWW8 [Direct mapping] Calcineurin-binding protein cabin-1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	2170 aa 240.8 kDa	No	0
CABIN1-202 ENSP00000481128 ENST00000620406	A0A087WXL7 [Direct mapping] Calcineurin-binding protein cabin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		589 aa 63.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.