Expression of SUSD2 in cancer - Summary - The Human Protein Atlas

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SUSD2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SUSD2
Gene description	Sushi domain containing 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (SK-BR-3)
HPA (normal tissue):	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and membranous expression, most abundant in lung and kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA004117
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004117

GENE INFORMATION
Gene name	SUSD2 (HGNC Symbol)
Synonyms	BK65A6.2, FLJ22778
Description	Sushi domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	24181259 - 24189110
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099994 (version 83.38)
Entrez gene	56241
UniProt	Q9UGT4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGT4
Antibodypedia	SUSD2 antibodies

PROTEIN BROWSER

SUSD2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SUSD2-001 ENSP00000351075 ENST00000358321	Q9UGT4 [Direct mapping] Sushi domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0030247 [polysaccharide binding] GO:0051782 [negative regulation of cell division] GO:0070062 [extracellular exosome] GO:1902807 [negative regulation of cell cycle G1/S phase transition] Show all	822 aa 90.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.