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SF3A1

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GENERAL INFORMATION

Gene name

 SF3A1

Gene description

 Splicing factor 3a, subunit 1, 120kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear speckles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA000690 , HPA030083
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear speckles.

Main location

 Nuclear speckles (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA030083 A-431 Nuclear speckles
HPA030083 U-2 OS Nuclear speckles
HPA030083 U-251 MG Nuclear speckles
HPA000690 A-431 Nuclear speckles
HPA000690 U-2 OS Nuclear speckles
HPA000690 U-251 MG Nuclear speckles

GENE INFORMATION

Gene name

 SF3A1 (HGNC Symbol)

Synonyms

 Prp21, PRPF21, SAP114, SF3a120

Description

 Splicing factor 3a, subunit 1, 120kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]

Chromosome

 22

Cytoband

 q12.2

Chromosome location (bp)

 30331988 - 30356947

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099995 (version 83.38)

Entrez gene

 10291

UniProt

 Q15459 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15459

Antibodypedia

 SF3A1 antibodies

PROTEIN BROWSER
SF3A1-001
SF3A1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SF3A1-001
ENSP00000215793
ENST00000215793
Q15459 [Direct mapping]
Splicing factor 3A subunit 1
A0A024R1K8 [Target identity:100%; Query identity:100%]
Splicing factor 3a, subunit 1, 120kDa, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000389 [mRNA 3'-splice site recognition]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005684 [U2-type spliceosomal complex]
GO:0005686 [U2 snRNP]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0044822 [poly(A) RNA binding]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
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 793 aa
88.9 kDa 		No 0
SF3A1-011
ENSP00000400862
ENST00000444440
H7C1L2 [Direct mapping]
Splicing factor 3A subunit 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005686 [U2 snRNP]
GO:0071004 [U2-type prespliceosome]
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 259 aa
28.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.