Expression of GGT5 in cancer - Summary - The Human Protein Atlas

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GGT5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GGT5
Gene description	Gamma-glutamyltransferase 5
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, HUVEC TERT2, LHCN-M2, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in stromal and endothelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 2 antibodies. HPA008121 , CAB032489
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), stomach cancer (unfavourable) and testis cancer (unfavourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008121	CAB032489

GENE INFORMATION
Gene name	GGT5 (HGNC Symbol)
Synonyms	GGT-REL, GGTLA1
Description	Gamma-glutamyltransferase 5 (HGNC Symbol)
Entrez gene summary	This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	24219654 - 24245142
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099998 (version 83.38)
Entrez gene	2687
UniProt	P36269 (UniProt - Evidence at protein level)
neXtProt	NX_P36269
Antibodypedia	GGT5 antibodies

PROTEIN BROWSER

GGT5-001	GGT5-002	GGT5-003	GGT5-004	GGT5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GGT5-001 ENSP00000330080 ENST00000327365	P36269 [Direct mapping] Gamma-glutamyltransferase 5 Gamma-glutamyltransferase 5 heavy chain Gamma-glutamyltransferase 5 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0016021 [integral component of membrane] GO:0019369 [arachidonic acid metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0036374 [glutathione hydrolase activity] GO:0044281 [small molecule metabolic process] Show all	586 aa 62.3 kDa	Yes	0
GGT5-002 ENSP00000263112 ENST00000263112	P36269 [Direct mapping] Gamma-glutamyltransferase 5 Gamma-glutamyltransferase 5 heavy chain Gamma-glutamyltransferase 5 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0016021 [integral component of membrane] GO:0019369 [arachidonic acid metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0036374 [glutathione hydrolase activity] GO:0044281 [small molecule metabolic process] Show all	554 aa 59 kDa	Yes	0
GGT5-003 ENSP00000381340 ENST00000398292	P36269 [Direct mapping] Gamma-glutamyltransferase 5 Gamma-glutamyltransferase 5 heavy chain Gamma-glutamyltransferase 5 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006520 [cellular amino acid metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006954 [inflammatory response] GO:0016021 [integral component of membrane] GO:0019369 [arachidonic acid metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0036374 [glutathione hydrolase activity] GO:0044281 [small molecule metabolic process] Show all	587 aa 62.3 kDa	Yes	0
GGT5-004 ENSP00000412964 ENST00000424217	C9JU68 [Direct mapping] Gamma-glutamyltransferase 5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	73 aa 7.4 kDa	Yes	0
GGT5-005 ENSP00000402917 ENST00000425408	H7C1X2 [Direct mapping] Gamma-glutamyltransferase 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	220 aa 23.1 kDa	No	0

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The Human Protein Atlas

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