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SEC14L2

GENERAL INFORMATION

Gene name

 SEC14L2

Gene description

 SEC14-like lipid binding 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (epididymis, liver, prostate)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA064466
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable) and breast cancer (favourable).
Head and neck cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA064466

GENE INFORMATION

Gene name

 SEC14L2 (HGNC Symbol)

Synonyms

 C22orf6, KIAA1186, KIAA1658, SPF, TAP, TAP1

Description

 SEC14-like lipid binding 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

Chromosome

 22

Cytoband

 q12.2

Chromosome location (bp)

 30396857 - 30425317

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100003 (version 83.38)

Entrez gene

 23541

UniProt

 O76054 (UniProt - Evidence at protein level)

neXtProt

 NX_O76054

Antibodypedia

 SEC14L2 antibodies

PROTEIN BROWSER
SEC14L2-001
SEC14L2-003
SEC14L2-004
SEC14L2-016
SEC14L2-021
SEC14L2-022
SEC14L2-027

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEC14L2-001
ENSP00000478755
ENST00000615189
O76054 [Direct mapping]
SEC14-like protein 2
A0A024R1I5 [Target identity:100%; Query identity:100%]
SEC14-like 2 (S. cerevisiae), isoform CRA_b
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   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006810 [transport]
GO:0008047 [enzyme activator activity]
GO:0008431 [vitamin E binding]
GO:0016021 [integral component of membrane]
GO:0016765 [transferase activity, transferring alkyl or aryl (other than methyl) groups]
GO:0043085 [positive regulation of catalytic activity]
GO:0045540 [regulation of cholesterol biosynthetic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070062 [extracellular exosome]
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 403 aa
46.1 kDa 		No 0
SEC14L2-003
ENSP00000482467
ENST00000617837
B3KRD8 [Direct mapping]
SEC14-like 2 (S. cerevisiae), isoform CRA_c; SEC14-like protein 2; cDNA FLJ34083 fis, clone FCBBF3004409, highly similar to SEC14-like protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
GO:0016021 [integral component of membrane]
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 329 aa
37.5 kDa 		No 0
SEC14L2-004
ENSP00000385186
ENST00000405717
O76054 [Direct mapping]
SEC14-like protein 2
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006810 [transport]
GO:0008431 [vitamin E binding]
GO:0016021 [integral component of membrane]
GO:0045540 [regulation of cholesterol biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070062 [extracellular exosome]
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 392 aa
44.7 kDa 		No 0
SEC14L2-016
ENSP00000387781
ENST00000428195
C9JZI9 [Direct mapping]
SEC14-like protein 2
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005622 [intracellular]
GO:0006810 [transport]
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 203 aa
23.3 kDa 		No 0
SEC14L2-021
ENSP00000407857
ENST00000429917
C9JYY7 [Direct mapping]
SEC14-like protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 85 aa
9.8 kDa 		No 0
SEC14L2-022
ENSP00000399596
ENST00000415072
C9JTM4 [Direct mapping]
SEC14-like protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 125 aa
14.2 kDa 		No 0
SEC14L2-027
ENSP00000383882
ENST00000402592
O76054 [Direct mapping]
SEC14-like protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006810 [transport]
GO:0008431 [vitamin E binding]
GO:0016021 [integral component of membrane]
GO:0045540 [regulation of cholesterol biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070062 [extracellular exosome]
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 320 aa
36.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.