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PES1

GENERAL INFORMATION

Gene name

 PES1

Gene description

 Pescadillo ribosomal biogenesis factor 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nucleolar expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA062439
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA062439

GENE INFORMATION

Gene name

 PES1 (HGNC Symbol)

Synonyms

 PES

Description

 Pescadillo ribosomal biogenesis factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]

Chromosome

 22

Cytoband

 q12.2

Chromosome location (bp)

 30576625 - 30607083

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100029 (version 83.38)

Entrez gene

 23481

UniProt

 O00541 (UniProt - Evidence at protein level)

neXtProt

 NX_O00541

Antibodypedia

 PES1 antibodies

PROTEIN BROWSER
PES1-001
PES1-002
PES1-003
PES1-004
PES1-005
PES1-010
PES1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PES1-001
ENSP00000346725
ENST00000354694
O00541 [Direct mapping]
Pescadillo homolog
B2RDF2 [Target identity:100%; Query identity:100%]
Pescadillo homolog
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000463 [maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000466 [maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000793 [condensed chromosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0007000 [nucleolus organization]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0030687 [preribosome, large subunit precursor]
GO:0033365 [protein localization to organelle]
GO:0042254 [ribosome biogenesis]
GO:0042273 [ribosomal large subunit biogenesis]
GO:0043021 [ribonucleoprotein complex binding]
GO:0044822 [poly(A) RNA binding]
GO:0051726 [regulation of cell cycle]
GO:0070545 [PeBoW complex]
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 588 aa
68 kDa 		No 0
PES1-002
ENSP00000385654
ENST00000405677
B3KXD6 [Direct mapping]
Pescadillo homolog; Pescadillo homolog 1, containing BRCT domain (Zebrafish), isoform CRA_b; cDNA FLJ45250 fis, clone BRHIP2008756, highly similar to Pescadillo homolog 1
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0042254 [ribosome biogenesis]
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 449 aa
51.5 kDa 		No 0
PES1-003
ENSP00000384366
ENST00000402281
B3KXD6 [Direct mapping]
Pescadillo homolog; Pescadillo homolog 1, containing BRCT domain (Zebrafish), isoform CRA_b; cDNA FLJ45250 fis, clone BRHIP2008756, highly similar to Pescadillo homolog 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0042254 [ribosome biogenesis]
Show all
 449 aa
51.5 kDa 		No 0
PES1-004
ENSP00000384252
ENST00000402284
B5MCF9 [Direct mapping]
Pescadillo homolog
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000463 [maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000466 [maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0030687 [preribosome, large subunit precursor]
GO:0042254 [ribosome biogenesis]
GO:0043021 [ribonucleoprotein complex binding]
Show all
 571 aa
66.1 kDa 		No 0
PES1-005
ENSP00000334612
ENST00000335214
O00541 [Direct mapping]
Pescadillo homolog
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000463 [maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000466 [maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0030687 [preribosome, large subunit precursor]
GO:0042254 [ribosome biogenesis]
GO:0042273 [ribosomal large subunit biogenesis]
GO:0043021 [ribonucleoprotein complex binding]
GO:0044822 [poly(A) RNA binding]
GO:0051726 [regulation of cell cycle]
GO:0070545 [PeBoW complex]
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 583 aa
67.5 kDa 		No 0
PES1-010
ENSP00000384777
ENST00000406208
H7BYY8 [Direct mapping]
Pescadillo homolog
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0042254 [ribosome biogenesis]
Show all
 135 aa
15.6 kDa 		No 0
PES1-013
ENSP00000404234
ENST00000441668
H7C267 [Direct mapping]
Pescadillo homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 194 aa
22.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.