Expression of ADRBK2 in cancer - Summary - The Human Protein Atlas

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ADRBK2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADRBK2
Gene description	Adrenergic, beta, receptor kinase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmixc expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA000804
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000804

GENE INFORMATION
Gene name	ADRBK2 (HGNC Symbol)
Synonyms	BARK2, GRK3
Description	Adrenergic, beta, receptor kinase 2 (HGNC Symbol)
Entrez gene summary	The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.1
Chromosome location (bp)	25564849 - 25729294
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100077 (version 83.38)
Entrez gene	157
UniProt	P35626 (UniProt - Evidence at protein level)
neXtProt	NX_P35626
Antibodypedia	ADRBK2 antibodies

PROTEIN BROWSER

ADRBK2-001	ADRBK2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADRBK2-001 ENSP00000317578 ENST00000324198	P35626 [Direct mapping] Beta-adrenergic receptor kinase 2 A0A024R1D8 [Target identity:100%; Query identity:100%] Adrenergic, beta, receptor kinase 2, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0031623 [receptor internalization] GO:0047696 [beta-adrenergic receptor kinase activity] Show all	688 aa 79.7 kDa	No	0
ADRBK2-201 ENSP00000478925 ENST00000619906	Q8N433 [Direct mapping] ADRBK2 protein; Beta-adrenergic receptor kinase 2 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004703 [G-protein coupled receptor kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] Show all	387 aa 44.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.