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PLA2G3

GENERAL INFORMATION

Gene name

 PLA2G3

Gene description

 Phospholipase A2, group III

Protein class

 Enzymes
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (AF22, AN3-CA, NTERA-2, SCLC-21H)
HPA (normal tissue):Tissue enhanced (esophagus, lung, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
HPA021016
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021016

GENE INFORMATION

Gene name

 PLA2G3 (HGNC Symbol)

Synonyms

 GIII-SPLA2

Description

 Phospholipase A2, group III (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]

Chromosome

 22

Cytoband

 q12.2

Chromosome location (bp)

 31134809 - 31140607

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100078 (version 83.38)

Entrez gene

 50487

UniProt

 Q9NZ20 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZ20

Antibodypedia

 PLA2G3 antibodies

PROTEIN BROWSER
PLA2G3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA2G3-001
ENSP00000215885
ENST00000215885
Q9NZ20 [Direct mapping]
Group 3 secretory phospholipase A2
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
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GO:0001675 [acrosome assembly]
GO:0004623 [phospholipase A2 activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005814 [centriole]
GO:0005886 [plasma membrane]
GO:0006644 [phospholipid metabolic process]
GO:0007288 [sperm axoneme assembly]
GO:0016042 [lipid catabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0042629 [mast cell granule]
GO:0043303 [mast cell degranulation]
GO:0044281 [small molecule metabolic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0047498 [calcium-dependent phospholipase A2 activity]
GO:0048468 [cell development]
GO:0060271 [cilium morphogenesis]
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 509 aa
57.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.