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Several cases of gliomas and melanomas as well as breast, endometrial and renal cancers showed moderate to strong immunoreactivity with occasional nuclear staining. Remaining cancer tissues were negative.
Melanomas and several gliomas showed moderate to strong cytoplasmic and nuclear immunoreactivity. Few cases of endometrial, thyroid, urothelial, breast and renal cancers showed weak to moderate staining. Remaining cancer tissues were negative or weak.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]