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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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LGALS1
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

LGALS1

Gene description

Lectin, galactoside-binding, soluble, 1

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissue types, including glomeruli, lymphoid tissues, fibroblasts and extracellular positivity.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA000646 , CAB002157
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), liver cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Liver cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA000646
CAB002157

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of gliomas and melanomas as well as breast, endometrial and renal cancers showed moderate to strong immunoreactivity with occasional nuclear staining. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Melanomas and several gliomas showed moderate to strong cytoplasmic and nuclear immunoreactivity. Few cases of endometrial, thyroid, urothelial, breast and renal cancers showed weak to moderate staining. Remaining cancer tissues were negative or weak.

GENE INFORMATION

Gene name

LGALS1 (HGNC Symbol)

Synonyms

GBP

Description

Lectin, galactoside-binding, soluble, 1 (HGNC Symbol)

Entrez gene summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q13.1

Chromosome location (bp)

37675608 - 37679806

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100097 (version 83.38)

Entrez gene

3956

UniProt

P09382 (UniProt - Evidence at protein level)

neXtProt

NX_P09382

Antibodypedia

LGALS1 antibodies

PROTEIN BROWSER

LGALS1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LGALS1-001
ENSP00000215909
ENST00000215909
P09382 [Direct mapping]
Galectin-1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0002317 [plasma cell differentiation]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0009986 [cell surface]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010977 [negative regulation of neuron projection development]
GO:0030246 [carbohydrate binding]
GO:0030395 [lactose binding]
GO:0031012 [extracellular matrix]
GO:0031295 [T cell costimulation]
GO:0033555 [multicellular organismal response to stress]
GO:0034120 [positive regulation of erythrocyte aggregation]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043236 [laminin binding]
GO:0044822 [poly(A) RNA binding]
GO:0045445 [myoblast differentiation]
GO:0046598 [positive regulation of viral entry into host cell]
GO:0048678 [response to axon injury]
GO:0070062 [extracellular exosome]
GO:0071333 [cellular response to glucose stimulus]
GO:0071407 [cellular response to organic cyclic compound]
Show all
135 aa
14.7 kDa
No 0

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