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PATZ1

GENERAL INFORMATION

Gene name

 PATZ1

Gene description

 POZ (BTB) and AT hook containing zinc finger 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA047893 , HPA048315
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), urothelial cancer (favourable), glioma (favourable) and lung cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Glioma p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047893
HPA048315

GENE INFORMATION

Gene name

 PATZ1 (HGNC Symbol)

Synonyms

 dJ400N23, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG

Description

 POZ (BTB) and AT hook containing zinc finger 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.2

Chromosome location (bp)

 31325804 - 31346232

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100105 (version 83.38)

Entrez gene

 23598

UniProt

 Q9HBE1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBE1

Antibodypedia

 PATZ1 antibodies

PROTEIN BROWSER
PATZ1-001
PATZ1-002
PATZ1-003
PATZ1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PATZ1-001
ENSP00000266269
ENST00000266269
Q9HBE1 [Direct mapping]
POZ-, AT hook-, and zinc finger-containing protein 1
A0A024R1M5 [Target identity:100%; Query identity:100%]
Zinc finger protein 278, isoform CRA_c
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0008584 [male gonad development]
GO:0010468 [regulation of gene expression]
GO:0030217 [T cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 687 aa
74.1 kDa 		No 0
PATZ1-002
ENSP00000384173
ENST00000405309
Q9HBE1 [Direct mapping]
POZ-, AT hook-, and zinc finger-containing protein 1
A0A024R1H7 [Target identity:100%; Query identity:100%]
Zinc finger protein 278, isoform CRA_b
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 537 aa
58 kDa 		No 0
PATZ1-003
ENSP00000215919
ENST00000215919
Q9HBE1 [Direct mapping]
POZ-, AT hook-, and zinc finger-containing protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 537 aa
57.6 kDa 		No 0
PATZ1-004
ENSP00000337520
ENST00000351933
Q9HBE1 [Direct mapping]
POZ-, AT hook-, and zinc finger-containing protein 1
A0A024R1F8 [Target identity:100%; Query identity:100%]
Zinc finger protein 278, isoform CRA_d
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 641 aa
69.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.