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Weak to moderate cytoplasmic staining was observed in most cancer tissues. Several skin cancers were negative.
GENE INFORMATION
Gene name
GCAT (HGNC Symbol)
Synonyms
KBL
Description
Glycine C-acetyltransferase (HGNC Symbol)
Entrez gene summary
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]
O75600 [Direct mapping] 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
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Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)