Expression of ANKRD54 in cancer - Summary - The Human Protein Atlas

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ANKRD54

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANKRD54
Gene description	Ankyrin repeat domain 54
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA071287
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), cervical cancer (favourable) and pancreatic cancer (favourable).
Endometrial cancer p<0.001 Cervical cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA071287

GENE INFORMATION
Gene name	ANKRD54 (HGNC Symbol)
Synonyms	LIAR
Description	Ankyrin repeat domain 54 (HGNC Symbol)
Entrez gene summary
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	37830855 - 37849327
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100124 (version 83.38)
Entrez gene	129138
UniProt	Q6NXT1 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NXT1
Antibodypedia	ANKRD54 antibodies

PROTEIN BROWSER

ANKRD54-001	ANKRD54-003	ANKRD54-004	ANKRD54-005	ANKRD54-006	ANKRD54-010	ANKRD54-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKRD54-001 ENSP00000215941 ENST00000215941	Q6NXT1 [Direct mapping] Ankyrin repeat domain-containing protein 54 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006913 [nucleocytoplasmic transport] GO:0019887 [protein kinase regulator activity] GO:0030496 [midbody] GO:0032403 [protein complex binding] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045859 [regulation of protein kinase activity] GO:1902531 [regulation of intracellular signal transduction] Show all	300 aa 32.5 kDa	No	0
ANKRD54-003 ENSP00000393035 ENST00000424350	C9JX82 [Direct mapping] Ankyrin repeat domain-containing protein 54 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	90 aa 9.8 kDa	No	0
ANKRD54-004 ENSP00000405782 ENST00000411961	D3YTC9 [Direct mapping] Ankyrin repeat domain-containing protein 54 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	284 aa 30.8 kDa	No	0
ANKRD54-005 ENSP00000387507 ENST00000434930	C9JU48 [Direct mapping] Ankyrin repeat domain-containing protein 54 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	217 aa 22.7 kDa	No	0
ANKRD54-006 ENSP00000412534 ENST00000458278	H7C3L3 [Direct mapping] Ankyrin repeat domain-containing protein 54 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	208 aa 23 kDa	No	0
ANKRD54-010 ENSP00000384392 ENST00000406423	B5MCX7 [Direct mapping] Ankyrin repeat domain-containing protein 54 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	180 aa 20.2 kDa	No	0
ANKRD54-013 ENSP00000477088 ENST00000609454	V9GYU2 [Direct mapping] Ankyrin repeat domain-containing protein 54 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 12.7 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.